Vesicular inhibitory amino acid transporter

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.[5]

SLC32A1
Identifiers
Aliases	SLC32A1, VGAT, VIAAT, solute carrier family 32 member 1
External IDs	OMIM: 616440 MGI: 1194488 HomoloGene: 56451 GeneCards: SLC32A1
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.23 Start 38,724,486 bp[1] End 38,729,372 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 158,610,767 bp[2] End 158,615,748 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • glycine transmembrane transporter activity • amino acid transmembrane transporter activity • gamma-aminobutyric acid:proton symporter activity Cellular component • integral component of membrane • membrane • synaptic vesicle • cell membrane • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane • synapse • inhibitory synapse • synaptic vesicle membrane • presynaptic active zone • dendrite terminus • dendrite • cone cell pedicle • intracellular organelle • cell tip • neuron projection • neuron projection terminus • cytoplasmic vesicle membrane • cytoplasmic vesicle • integral component of synaptic vesicle membrane • GABA-ergic synapse Biological process • amino acid transmembrane transport • aging • ion transport • gamma-aminobutyric acid transport • neurotransmitter transport • hippocampus development • GO:0010554 neurotransmitter secretion • glycine transport • neurotransmitter loading into synaptic vesicle Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140679	22348
Ensembl	ENSG00000101438	ENSMUSG00000037771
UniProt	Q9H598	O35633
RefSeq (mRNA)	NM_080552	NM_009508
RefSeq (protein)	NP_542119	NP_033534
Location (UCSC)	Chr 20: 38.72 – 38.73 Mb	Chr 2: 158.61 – 158.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II.[5]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000101438 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037771 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1".

Further reading

• McIntire SL, Reimer RJ, Schuske K, et al. (1997). "Identification and characterization of the vesicular GABA transporter". Nature. 389 (6653): 870–6. doi:10.1038/39908. PMID 9349821. S2CID 4404823.
• Kleiderlein JJ, Nisson PE, Jessee J, et al. (1999). "CCG repeats in cDNAs from human brain". Hum. Genet. 103 (6): 666–73. doi:10.1007/s004390050889. PMID 9921901. S2CID 23696667.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Chessler SD, Simonson WT, Sweet IR, Hammerle LP (2002). "Expression of the vesicular inhibitory amino acid transporter in pancreatic islet cells: distribution of the transporter within rat islets". Diabetes. 51 (6): 1763–71. doi:10.2337/diabetes.51.6.1763. PMID 12031963.
• Jellali A, Stussi-Garaud C, Gasnier B, et al. (2002). "Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina". J. Comp. Neurol. 449 (1): 76–87. doi:10.1002/cne.10272. PMID 12115694. S2CID 27646744.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Geigerseder C, Doepner R, Thalhammer A, et al. (2003). "Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors". Neuroendocrinology. 77 (5): 314–23. doi:10.1159/000070897. PMID 12806177. S2CID 7652352.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.