Vesicular glutamate transporter 1

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.[5][6][7]

SLC17A7
Identifiers
Aliases	SLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDs	OMIM: 605208 MGI: 1920211 HomoloGene: 113454 GeneCards: SLC17A7
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,429,401 bp[1] End 49,442,360 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,163,949 bp[2] End 45,176,142 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • inorganic phosphate transmembrane transporter activity • sodium:inorganic phosphate symporter activity • extracellular-glutamate-gated chloride channel activity • symporter activity • L-glutamate transmembrane transporter activity • neurotransmitter transporter activity Cellular component • postsynapse • integral component of membrane • membrane • synaptic vesicle • cell membrane • synapse • excitatory synapse • synaptic vesicle membrane • cerebellar mossy fiber • presynaptic active zone • cell junction • intracellular organelle • neuron projection • clathrin-sculpted glutamate transport vesicle membrane • cytoplasmic vesicle • integral component of synaptic vesicle membrane Biological process • phosphate ion transport • synaptic transmission, glutamatergic • sodium-dependent phosphate transport • sodium ion transport • chloride transmembrane transport • ion transport • glutamate secretion • synaptic vesicle lumen acidification • brain development • long-term memory • excitatory postsynaptic potential • neurotransmitter transport • neural retina development • L-glutamate import • sequestering of neurotransmitter • sodium ion transmembrane transport • transmembrane transport • chemical synaptic transmission • neurotransmitter loading into synaptic vesicle • L-glutamate transport • regulation of synaptic vesicle endocytosis • regulation of synapse structure or activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57030	72961
Ensembl	ENSG00000104888	ENSMUSG00000070570
UniProt	Q9P2U7	Q3TXX4
RefSeq (mRNA)	NM_020309	NM_182993
RefSeq (protein)	NP_064705	NP_892038
Location (UCSC)	Chr 19: 49.43 – 49.44 Mb	Chr 7: 45.16 – 45.18 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.[7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000104888 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070570 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143. S2CID 23177236.
6. Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226. S2CID 37857748.
7. "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

Further reading

• Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH (2000). "Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter". Science. 289 (5481): 957–60. doi:10.1126/science.289.5481.957. PMID 10938000.
• Takamori S, Rhee JS, Rosenmund C, Jahn R (2000). "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons". Nature. 407 (6801): 189–94. doi:10.1038/35025070. hdl:11858/00-001M-0000-0012-F987-C. PMID 11001057. S2CID 4412622.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons". Schizophrenia Research. 73 (2–3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259. S2CID 2335413.
• Alonso-Nanclares L, De Felipe J (2005). "Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex". Neuroscience. 134 (1): 59–68. doi:10.1016/j.neuroscience.2005.03.038. PMID 15961236. S2CID 25943855.
• Vinatier J, Herzog E, Plamont MA, et al. (2006). "Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis". J. Neurochem. 97 (4): 1111–25. doi:10.1111/j.1471-4159.2006.03821.x. PMID 16606361. S2CID 3133505.
• Almqvist J, Huang Y, Laaksonen A, et al. (2007). "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters". Protein Sci. 16 (9): 1819–29. doi:10.1110/ps.072944707. PMC 2206968. PMID 17660252.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.