SLC45A4

SLC45A4
Identifiers
Aliases	SLC45A4, solute carrier family 45 member 4
External IDs	MGI: 2146236 HomoloGene: 69908 GeneCards: SLC45A4
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	141,308,305 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	73,645,762 bp[2]
Gene ontology
Molecular function	• sucrose:proton symporter activity;
Cellular component	• membrane; • integral component of membrane;
Biological process	• sucrose transport;
	Sources:Amigo / QuickGO
Orthologs
	57210
	106068
	ENSG00000022567
	ENSMUSG00000079020
	Q5BKX6
	Q0P5V9
	NM_001080431; NM_001286646; NM_001286648
	NM_001033219; NM_001168255; NM_001357747
	NP_001073900; NP_001273575; NP_001273577
	NP_001028391; NP_001161727; NP_001344676
	Wikidata
View/Edit Human	View/Edit Mouse

SLC45A4 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, sucrose, as well simple sugars such as glucose and fructose (ii) perform secondary active transport in a proton-dependent manner.[5]

It is associated with sugar transport in the spermatozoa.[6] Additionally, it has been itdentified as a necessary component in the cell death caused of the compound paraquat.[7]

References

GRCh38: Ensembl release 89: ENSG00000022567 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000079020 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O (December 2014). "Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae". The Biochemical Journal. 464 (2): 193–201. doi:10.1042/BJ20140572. PMID 25164149.
Vitavska O, Wieczorek H (November 2017). "+/sugar cotransporter in mammalian spermatozoa". Pflügers Archiv. 469 (11): 1433–1442. doi:10.1007/s00424-017-2024-9. PMC 5629229. PMID 28689241.
Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, et al. (December 2017). "A CRISPR screen identifies a pathway required for paraquat-induced cell death". Nature Chemical Biology. 13 (12): 1274–1279. doi:10.1038/nchembio.2499. PMC 5698099. PMID 29058724.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000022567 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079020 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O (December 2014). "Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae". The Biochemical Journal. 464 (2): 193–201. doi:10.1042/BJ20140572. PMID 25164149.

[6] Vitavska O, Wieczorek H (November 2017). "+/sugar cotransporter in mammalian spermatozoa". Pflügers Archiv. 469 (11): 1433–1442. doi:10.1007/s00424-017-2024-9. PMC 5629229. PMID 28689241.

[7] Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, et al. (December 2017). "A CRISPR screen identifies a pathway required for paraquat-induced cell death". Nature Chemical Biology. 13 (12): 1274–1279. doi:10.1038/nchembio.2499. PMC 5698099. PMID 29058724.