SLC5A4

The low affinity sodium-glucose cotransporter also known as the sodium/glucose cotransporter 3 (SGLT3) or solute carrier family 5 member 4 (SLC5A4) is a protein that in humans is encoded by the SLC5A4 gene.[3][4][5] It functions as a sugar sensor.

SLC5A4
Identifiers
Aliases	SLC5A4, DJ90G24.4, SAAT1, SGLT3, solute carrier family 5 member 4
External IDs	HomoloGene: 8591 GeneCards: SLC5A4
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.3 Start 32,218,476 bp[1] End 32,255,341 bp[1]
Gene ontology Molecular function • glucose:sodium symporter activity • GO:0022891 transmembrane transporter activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • cell membrane Biological process • ion transport • transmembrane transport • sodium ion transport • glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6527	n/a
Ensembl	ENSG00000100191	n/a
UniProt	Q9NY91	n/a
RefSeq (mRNA)	NM_014227	n/a
RefSeq (protein)	NP_055042	n/a
Location (UCSC)	Chr 22: 32.22 – 32.26 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000100191 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: solute carrier family 5 (low affinity glucose cotransporter)".
4. Veyhl M, Wagner K, Volk C, Gorboulev V, Baumgarten K, Weber WM, Schaper M, Bertram B, Wiessler M, Koepsell H (March 1998). "Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1". Proceedings of the National Academy of Sciences of the United States of America. 95 (6): 2914–9. doi:10.1073/pnas.95.6.2914. PMC 19669. PMID 9501190.
5. Jung H (October 2002). "The sodium/substrate symporter family: structural and functional features". FEBS Letters. 529 (1): 73–7. doi:10.1016/S0014-5793(02)03184-8. PMID 12354616.

Further reading

• Munafò MR, Clark TG, Roberts KH, Johnstone EC (2006). "Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression". Neuropsychobiology. 53 (1): 1–8. doi:10.1159/000089915. PMID 16319503.
• Blaya C, Salum GA, Lima MS, Leistner-Segal S, Manfro GG (2007). "Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis". Behavioral and Brain Functions. 3: 41. doi:10.1186/1744-9081-3-41. PMC 1994953. PMID 17705872.
• Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H (September 2003). "A glucose sensor hiding in a family of transporters". Proceedings of the National Academy of Sciences of the United States of America. 100 (20): 11753–8. doi:10.1073/pnas.1733027100. PMC 208830. PMID 13130073.
• Fairchild TJ (January 2008). "Protection of muscle membrane excitability during cycling in humans: a role for SGLT3?". Journal of Applied Physiology. 104 (1): 315, author reply 316. doi:10.1152/japplphysiol.00793.2007. PMID 18198291.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM (February 2007). "Imino sugars are potent agonists of the human glucose sensor SGLT3". Molecular Pharmacology. 71 (2): 628–34. doi:10.1124/mol.106.030288. PMID 17110502.