SLC13A5

Solute carrier family 13 (sodium-dependent citrate transporter), member 5 also known as the Na⁺/citrate cotransporter or mIndy is a protein that in humans is encoded by the SLC13A5 gene.[5] It is the mammalian homolog of the fly Indy (gene).

SLC13A5
Identifiers
Aliases	SLC13A5, EIEE25, NACT, mIndy, solute carrier family 13 member 5, INDY
External IDs	OMIM: 608305 MGI: 3037150 HomoloGene: 21941 GeneCards: SLC13A5
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 6,684,719 bp[1] End 6,713,377 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 72,241,989 bp[2] End 72,267,222 bp[2]
Gene ontology Molecular function • transporter activity • tricarboxylic acid transmembrane transporter activity • symporter activity • succinate transmembrane transporter activity • sodium:dicarboxylate symporter activity • citrate transmembrane transporter activity Cellular component • integral component of membrane • integral component of plasma membrane • membrane • cell membrane Biological process • tricarboxylic acid transport • succinate transmembrane transport • ion transport • succinate transport • sodium ion transport • transmembrane transport • tricarboxylic acid transmembrane transport • citrate transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	284111	237831
Ensembl	ENSG00000141485	ENSMUSG00000020805
UniProt	Q86YT5	Q67BT3
RefSeq (mRNA)	NM_001143838 NM_001284509 NM_001284510 NM_177550	NM_001004148 NM_001372402 NM_001372403
RefSeq (protein)	NP_001137310 NP_001271438 NP_001271439 NP_808218	NP_001004148 NP_001359331 NP_001359332
Location (UCSC)	Chr 17: 6.68 – 6.71 Mb	Chr 11: 72.24 – 72.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SLC13A5 is a tricarboxylate plasma transporter with a preference for citrate.[5]

Clinical significance

In 2014, by means of exome sequencing it was determined that a genetic mutation of the SLC13A5 gene is the cause of an extremely rare citrate transporter disorder.[6] Mutations in SLC13A5 cause autosomal recessive epileptic encephalopathy with seizure onset in the first days of life.[6] Those afflicted suffer from seizures, global developmental delay, movement disorder and hypotonia.

Reduced expression of this gene is associated with longer lifespan in many organisms, including some non-human primates. Increased expression is associated with type 2 diabetes and non-alcoholic fatty liver disease. A sugary diet upregulates the expression of the gene, and so does Interleukin 6 signaling.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000141485 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020805 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 13 (sodium-dependent citrate transporter), member 5".
6. Thevenon J, Milh M, Feillet F, St-Onge J, Duffourd Y, Jugé C, et al. (July 2014). "Mutations in SLC13A5 cause autosomal-recessive epileptic encephalopathy with seizure onset in the first days of life". American Journal of Human Genetics. 95 (1): 113–20. doi:10.1016/j.ajhg.2014.06.006. PMC 4085634. PMID 24995870.
7. von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, et al. (August 2017). "The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism". Hepatology. 66 (2): 616–630. doi:10.1002/hep.29089. PMC 5519435. PMID 28133767.

Further reading

• Pajor AM (February 2006). "Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters". Pflügers Archiv. 451 (5): 597–605. doi:10.1007/s00424-005-1487-2. PMC 1866268. PMID 16211368.
• Inoue K, Zhuang L, Ganapathy V (December 2002). "Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function". Biochemical and Biophysical Research Communications. 299 (3): 465–71. doi:10.1016/S0006-291X(02)02669-4. PMID 12445824.
• Gopal E, Miyauchi S, Martin PM, Ananth S, Srinivas SR, Smith SB, Prasad PD, Ganapathy V (January 2007). "Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines". American Journal of Physiology. Gastrointestinal and Liver Physiology. 292 (1): G402-8. doi:10.1152/ajpgi.00371.2006. PMID 16973915.
• Benjamin DJ, Cesarini D, van der Loos MJ, Dawes CT, Koellinger PD, Magnusson PK, Chabris CF, Conley D, Laibson D, Johannesson M, Visscher PM (May 2012). "The genetic architecture of economic and political preferences". Proceedings of the National Academy of Sciences of the United States of America. 109 (21): 8026–31. Bibcode:2012PNAS..109.8026B. doi:10.1073/pnas.1120666109. PMC 3361436. PMID 22566634.
• Inoue K, Zhuang L, Maddox DM, Smith SB, Ganapathy V (August 2003). "Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action". The Biochemical Journal. 374 (Pt 1): 21–6. doi:10.1042/BJ20030827. PMC 1223593. PMID 12826022.

External links

• tessresearch.org - A foundation dedicated to SLC13A5 disorders.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.