SLC26A6

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.[4][5][6] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[7]

SLC26A6
Identifiers
Aliases	SLC26A6, solute carrier family 26 member 6
External IDs	OMIM: 610068 MGI: 2159728 HomoloGene: 99903 GeneCards: SLC26A6
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 48,625,723 bp[1] End 48,635,493 bp[1]
Gene ontology Molecular function • PDZ domain binding • GO:0015659 formate transmembrane transporter activity • chloride transmembrane transporter activity • anion transmembrane transporter activity • anion:anion antiporter activity • sulfate transmembrane transporter activity • secondary active sulfate transmembrane transporter activity • bicarbonate transmembrane transporter activity • formate efflux transmembrane transporter activity • oxalate transmembrane transporter activity • GO:0001948 protein binding • efflux transmembrane transporter activity • antiporter activity • chloride channel activity • inorganic anion exchanger activity Cellular component • integral component of membrane • membrane • intracellular membrane-bounded organelle • vesicle membrane • cell membrane • integral component of plasma membrane • chloride channel complex • brush border membrane • basolateral plasma membrane • apical plasma membrane • endoplasmic reticulum • sperm midpiece • cytoplasmic vesicle membrane • cytoplasmic vesicle • intracellular • vesicle Biological process • oxalic acid secretion • mannitol transport • oxalate transport • formate transport • intracellular pH elevation • sulfate transport • epithelial fluid transport • angiotensin-activated signaling pathway • regulation of membrane potential • regulation of intracellular pH • cellular response to fructose stimulus • ion transport • transepithelial chloride transport • protein kinase C signaling • anion transport • transepithelial transport • cellular response to interferon-gamma • sperm capacitation • intestinal absorption • chloride transport • positive regulation of dipeptide transmembrane transport • cellular response to cAMP • anion transmembrane transport • sulfate transmembrane transport • bicarbonate transport • transmembrane transport • chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	65010	171429
Ensembl	ENSG00000225697	ENSMUSG00000023259
UniProt	Q9BXS9	Q8CIW6
RefSeq (mRNA)	NM_134426 NM_001040454 NM_001281732 NM_001281733 NM_022911 NM_134263	NM_134420
RefSeq (protein)	NP_001035544 NP_001268661 NP_001268662 NP_075062 NP_599025 NP_602298 NP_001035544.1	NP_599252
Location (UCSC)	Chr 3: 48.63 – 48.64 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.[6]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000225697 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Lohi H; Kujala M; Kerkela E; Saarialho-Kere U; Kestila M; Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID 11087667.
5. Waldegger S; Moschen I; Ramirez A; Smith RJ; Ayadi H; Lang F; Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665.
6. "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
7. Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957–C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486.

Further reading

• Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495.
• Ignatovich O, Tomlinson IM, Popov AV, et al. (2000). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire". J. Mol. Biol. 294 (2): 457–65. doi:10.1006/jmbi.1999.3243. PMID 10610771.
• Xie Q, Welch R, Mercado A, et al. (2002). "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1". Am. J. Physiol. Renal Physiol. 283 (4): F826–38. doi:10.1152/ajprenal.00079.2002. PMID 12217875.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chernova MN, Jiang L, Friedman DJ, et al. (2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". J. Biol. Chem. 280 (9): 8564–80. doi:10.1074/jbc.M411703200. PMID 15548529.
• Kujala M, Tienari J, Lohi H, et al. (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron Exp. Nephrol. 101 (2): e50–8. doi:10.1159/000086345. PMID 15956810. S2CID 26671784.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Shcheynikov N, Wang Y, Park M, et al. (2006). "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6". J. Gen. Physiol. 127 (5): 511–24. doi:10.1085/jgp.200509392. PMC 2151520. PMID 16606687.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Alper SL, Stewart AK, Chernova MN, et al. (2007). "Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides". Novartis Found. Symp. Novartis Foundation Symposia. 273: 107–19, discussion 119–25, 261–4. doi:10.1002/0470029579.ch8. ISBN 9780470016244. PMID 17120764.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.