SLC6A14

Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14) is a protein that in humans is encoded by the SLC6A14 gene.[5][6]

SLC6A14
Identifiers
Aliases	SLC6A14, BMIQ11, solute carrier family 6 member 14
External IDs	OMIM: 300444 MGI: 1890216 HomoloGene: 38290 GeneCards: SLC6A14
Gene location (Human) Chr. X chromosome (human)[1] Band Xq23 Start 116,436,606 bp[1] End 116,461,458 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A2 Start 21,714,896 bp[2] End 21,742,355 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • symporter activity • amino acid transmembrane transporter activity • neurotransmitter:sodium symporter activity • transporter activity Cellular component • integral component of plasma membrane • membrane • brush border membrane • vesicle • extracellular exosome • integral component of membrane • cell membrane Biological process • neurotransmitter transport • amino acid transport • cellular amino acid metabolic process • response to toxic substance • transmembrane transport • amino acid transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11254	56774
Ensembl	ENSG00000268104	ENSMUSG00000031089
UniProt	Q9UN76	Q9JMA9
RefSeq (mRNA)	NM_007231	NM_020049
RefSeq (protein)	NP_009162	NP_064433
Location (UCSC)	Chr X: 116.44 – 116.46 Mb	Chr X: 21.71 – 21.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SLC6A14 is a member of the Na⁺- and Cl⁻-dependent neurotransmitter transporter family and transports both neutral and cationic amino acids in an Na⁺- and Cl⁻-dependent manner.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000268104 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031089 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sloan JL, Mager S (Sep 1999). "Cloning and functional expression of a human Na(+) and Cl(−)-dependent neutral and cationic amino acid transporter B(0+)". J Biol Chem. 274 (34): 23740–5. doi:10.1074/jbc.274.34.23740. PMID 10446133.
6. "Entrez Gene: SLC6A14 solute carrier family 6 (amino acid transporter), member 14".

Further reading

• Ohman M, Oksanen L, Kaprio J, Koskenvuo M, Mustajoki P, Rissanen A, Salmi J, Kontula K, Peltonen L (2000). "Genome-wide scan of obesity in Finnish sibpairs reveals linkage to chromosome Xq24". J. Clin. Endocrinol. Metab. 85 (9): 3183–90. doi:10.1210/jc.85.9.3183. PMID 10999806.
• Sloan JL, Grubb BR, Mager S (2003). "Expression of the amino acid transporter ATB 0+ in lung: possible role in luminal protein removal". Am. J. Physiol. Lung Cell Mol. Physiol. 284 (1): L39–49. doi:10.1152/ajplung.00164.2002. PMID 12388375.
• Suviolahti E, Oksanen LJ, Ohman M, Cantor RM, Ridderstrale M, Tuomi T, Kaprio J, Rissanen A, Mustajoki P, Jousilahti P, Vartiainen E, Silander K, Kilpikari R, Salomaa V, Groop L, Kontula K, Peltonen L, Pajukanta P (2004). "The SLC6A14 gene shows evidence of association with obesity". J. Clin. Invest. 112 (11): 1762–72. doi:10.1172/JCI17491. PMC 281637. PMID 14660752.
• Durand E, Boutin P, Meyre D, Charles MA, Clement K, Dina C, Froguel P (2004). "Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians". Diabetes. 53 (9): 2483–6. doi:10.2337/diabetes.53.9.2483. PMID 15331564.
• Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K, Mager S, Prasad PD, Ganapathy ME, Ganapathy V (2005). "Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans". Biochim. Biophys. Acta. 1741 (1–2): 215–23. doi:10.1016/j.bbadis.2005.04.002. PMID 15905073.