Chloride potassium symporter 4

Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4.[5]

SLC12A4
Identifiers
Aliases	SLC12A4, KCC1, Chloride potassium symporter 4, CTC-479C5.17, hKCC1, solute carrier family 12 member 4
External IDs	OMIM: 604119 MGI: 1309465 HomoloGene: 21056 GeneCards: SLC12A4
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,943,474 bp[1] End 67,969,601 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.06 cM Start 105,943,590 bp[2] End 105,966,097 bp[2]
Gene ontology Molecular function • cation:chloride symporter activity • symporter activity • transporter activity • protein kinase binding • potassium:chloride symporter activity Cellular component • lysosomal membrane • cell membrane • membrane • integral component of membrane • integral component of plasma membrane Biological process • ion transport • chemical synaptic transmission • cell volume homeostasis • potassium ion transport • potassium ion transmembrane transport • transmembrane transport • chloride transmembrane transport • chloride transport • transport • chloride ion homeostasis • potassium ion homeostasis • potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6560	20498
Ensembl	ENSG00000124067	ENSMUSG00000017765
UniProt	Q9UP95	Q9JIS8
RefSeq (mRNA)	NM_005072 NM_001145961 NM_001145962 NM_001145963 NM_001145964	NM_001253804 NM_009195
RefSeq (protein)	NP_001139433 NP_001139434 NP_001139435 NP_001139436 NP_005063	NP_001240733 NP_033221
Location (UCSC)	Chr 16: 67.94 – 67.97 Mb	Chr 8: 105.94 – 105.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000124067 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017765 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SLC12A4 solute carrier family 12 (potassium/chloride transporters), member 4".

Further reading

• Larsen F, Solheim J, Kristensen T, et al. (1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum. Mol. Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911.
• Gillen CM, Brill S, Payne JA, Forbush B (1996). "Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family". J. Biol. Chem. 271 (27): 16237–44. doi:10.1074/jbc.271.27.16237. PMID 8663127.
• Pellegrino CM, Rybicki AC, Musto S, et al. (1998). "Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells". Blood Cells Mol. Dis. 24 (1): 31–40. doi:10.1006/bcmd.1998.0168. PMID 9516379.
• Su W, Shmukler BE, Chernova MN, et al. (1999). "Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation". Am. J. Physiol. 277 (5 Pt 1): C899–912. doi:10.1152/ajpcell.1999.277.5.C899. PMID 10564083.
• Casula S, Shmukler BE, Wilhelm S, et al. (2001). "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity". J. Biol. Chem. 276 (45): 41870–8. doi:10.1074/jbc.M107155200. PMID 11551954.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl⁻ channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.
• Shen MR, Chou CY, Hsu KF, et al. (2003). "KCl cotransport is an important modulator of human cervical cancer growth and invasion". J. Biol. Chem. 278 (41): 39941–50. doi:10.1074/jbc.M308232200. PMID 12902337.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhou GP, Wong C, Su R, et al. (2004). "Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element". Blood. 103 (11): 4302–9. doi:10.1182/blood-2003-01-0107. PMID 14976052.
• Khan AI, Drew C, Ball SE, et al. (2005). "Oxygen dependence of K⁺–Cl⁻ cotransport in human red cell ghosts and sickle cells". Bioelectrochemistry (Amsterdam, Netherlands). 62 (2): 141–6. doi:10.1016/j.bioelechem.2003.07.005. PMID 15039017.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.