Monocarboxylate transporter 10

Monocarboxylate transporter 10 (MCT 10), also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene.[5][6][7] SLC16A10 is a member of the solute carrier family.

SLC16A10
Identifiers
Aliases	SLC16A10, MCT10, PRO0813, TAT1, solute carrier family 16 member 10
External IDs	OMIM: 607550 MGI: 1919722 HomoloGene: 75089 GeneCards: SLC16A10
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 111,087,503 bp[1] End 111,231,194 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B1 Start 40,033,532 bp[2] End 40,142,258 bp[2]
Gene ontology Molecular function • aromatic amino acid transmembrane transporter activity • thyroid hormone transmembrane transporter activity • amino acid transmembrane transporter activity • monocarboxylic acid transmembrane transporter activity Cellular component • cell membrane • basolateral plasma membrane • integral component of plasma membrane • membrane • integral component of membrane Biological process • thyroid hormone transport • amino acid transport • aromatic amino acid transport • transmembrane transport • amino acid transmembrane transport • monocarboxylic acid transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117247	72472
Ensembl	ENSG00000112394	ENSMUSG00000019838
UniProt	Q8TF71	Q3U9N9
RefSeq (mRNA)	NM_018593	NM_001114332 NM_028247
RefSeq (protein)	NP_061063	NP_001107804 NP_082523
Location (UCSC)	Chr 6: 111.09 – 111.23 Mb	Chr 10: 40.03 – 40.14 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

SLC16A10 mediates Na⁺-independent transport of tryptophan, tyrosine, phenylalanine, and L-DOPA.[7]

See also

• Blue diaper syndrome

References

1. GRCh38: Ensembl release 89: ENSG00000112394 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019838 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 16".
6. Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H (May 2001). "Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters". J. Biol. Chem. 276 (20): 17221–8. doi:10.1074/jbc.M009462200. PMID 11278508.
7. Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H (January 2002). "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location". Genomics. 79 (1): 95–103. doi:10.1006/geno.2001.6678. PMID 11827462.

Further reading

• Toure A, Morin L, Pineau C, et al. (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.
• Friesema EC, Jansen J, Jachtenberg JW, et al. (2008). "Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10". Mol. Endocrinol. 22 (6): 1357–69. doi:10.1210/me.2007-0112. PMC 5419535. PMID 18337592.
• Loubière LS, Vasilopoulou E, Bulmer JN, et al. (2010). "Expression of thyroid hormone transporters in the human placenta and changes associated with intrauterine growth restriction" (PDF). Placenta. 31 (4): 295–304. doi:10.1016/j.placenta.2010.01.013. PMID 20167367.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bröer S (2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088. S2CID 1834804.
• Park SY, Kim JK, Kim IJ, et al. (2005). "Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule". Arch. Pharm. Res. 28 (4): 421–32. doi:10.1007/BF02977671. PMID 15918515. S2CID 2139640.
• Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169. S2CID 15498611.