ZBTB7A

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.[5][6][7]

ZBTB7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IF5, 2NN2
Identifiers
Aliases	ZBTB7A, FBI-1, FBI1, LRF, ZBTB7, ZNF857A, pokemon, TIP21, zinc finger and BTB domain containing 7A
External IDs	OMIM: 605878 MGI: 1335091 HomoloGene: 7820 GeneCards: ZBTB7A
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,043,303 bp[1] End 4,066,899 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 81,135,220 bp[2] End 81,152,995 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948 protein binding • histone acetyltransferase binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription corepressor binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001106 transcription corepressor activity • activating transcription factor binding • sequence-specific DNA binding • SMAD binding • androgen receptor binding Cellular component • cell nucleus • cytoplasm • NuRD complex • site of double-strand break • DNA-dependent protein kinase complex Biological process • multicellular organism development • cell differentiation • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of alternative mRNA splicing, via spliceosome • regulation of glycolytic process • chromatin organization • chromatin remodeling • cellular response to DNA damage stimulus • B cell differentiation • negative regulation of transforming growth factor beta receptor signaling pathway • protein localization to nucleus • regulation of apoptotic process • erythrocyte maturation • fat cell differentiation • negative regulation of Notch signaling pathway • regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • negative regulation of androgen receptor signaling pathway • double-strand break repair via classical nonhomologous end joining • regulation of transcription regulatory region DNA binding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51341	16969
Ensembl	ENSG00000178951	ENSMUSG00000035011
UniProt	O95365	O88939
RefSeq (mRNA)	NM_015898 NM_001317990	NM_010731
RefSeq (protein)	NP_001304919 NP_056982	NP_034861
Location (UCSC)	Chr 19: 4.04 – 4.07 Mb	Chr 10: 81.14 – 81.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

ZBTB7A has been shown to interact with BCL6.[8]

See also

• Zbtb7

References

1. GRCh38: Ensembl release 89: ENSG00000178951 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035011 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Morrison DJ, Pendergrast PS, Stavropoulos P, Colmenares SU, Kobayashi R, Hernandez N (Apr 1999). "FBI-1, a factor that binds to the HIV-1 inducer of short transcripts (IST), is a POZ domain protein". Nucleic Acids Res. 27 (5): 1251–62. doi:10.1093/nar/27.5.1251. PMC 148309. PMID 9973611.
6. Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (Feb 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID 9927193.
7. "Entrez Gene: ZBTB7A zinc finger and BTB domain containing 7A".
8. Davies JM, Hawe N, Kabarowski J, Huang QH, Zhu J, Brand NJ, Leprince D, Dhordain P, Cook M, Morriss-Kay G, Zelent A (January 1999). "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene". Oncogene. 18 (2): 365–75. doi:10.1038/sj.onc.1202332. PMID 9927193.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Pendergrast PS, Wang C, Hernandez N, Huang S (2002). "FBI-1 Can Stimulate HIV-1 Tat Activity and Is Targeted to a Novel Subnuclear Domain that Includes the Tat-P-TEFb—containing Nuclear Speckles". Mol. Biol. Cell. 13 (3): 915–29. doi:10.1091/mbc.01-08-0383. PMC 99609. PMID 11907272.
• Lee DK, Suh D, Edenberg HJ, Hur MW (2002). "POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1". J. Biol. Chem. 277 (30): 26761–8. doi:10.1074/jbc.M202078200. PMID 12004059.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Pessler F, Hernandez N (2003). "Flexible DNA binding of the BTB/POZ-domain protein FBI-1". J. Biol. Chem. 278 (31): 29327–35. doi:10.1074/jbc.M302980200. PMID 12750370.
• Laudes M, Christodoulides C, Sewter C, et al. (2004). "Role of the POZ zinc finger transcription factor FBI-1 in human and murine adipogenesis". J. Biol. Chem. 279 (12): 11711–8. doi:10.1074/jbc.M310240200. PMC 4303998. PMID 14701838.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Liu CJ, Prazak L, Fajardo M, et al. (2004). "Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis". J. Biol. Chem. 279 (45): 47081–91. doi:10.1074/jbc.M405288200. PMID 15337766.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Maeda T, Hobbs RM, Merghoub T, et al. (2005). "Role of the proto-oncogene Pokémon in cellular transformation and ARF repression". Nature. 433 (7023): 278–85. doi:10.1038/nature03203. PMID 15662416. S2CID 4308742.
• Lee DK, Kang JE, Park HJ, et al. (2005). "FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB". J. Biol. Chem. 280 (30): 27783–91. doi:10.1074/jbc.M504909200. PMID 15917220.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Roh HE, Lee MN, Jeon BN, et al. (2007). "Regulation of Pokémon 1 activity by sumoylation". Cell. Physiol. Biochem. 20 (1–4): 167–80. doi:10.1159/000104164. PMID 17595526.

External links

• ZBTB7A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook ZBTB7A

This article incorporates text from the United States National Library of Medicine, which is in the public domain.