Pho4

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Structures	Swiss-model
Domains	InterPro

Pho4
	Crystallographic structure of yeast Pho4 homodimer (cyan and green) complexed with DNA (brown).[1]
Identifiers
Symbol	Pho4
Alt. symbols	YFR034C
NCBI gene	850594
PDB	1a0a
RefSeq	NP_116692
UniProt	P07270
Search for
Structures	Swiss-model
Domains	InterPro

Pho4 is a basic helix-loop-helix (bHLH) transcription factor found in S. cerevisiae and other yeasts.[2]

The Pho4 homodimer binds to DNA sequences containing the bHLH binding site 5'-CACGTG-3'.[3] This sequence is found in the promoters of genes upregulated in response to phosphate availability such as the PHO5 gene.[4]

References

PDB: 1a0a; Shimizu T, Toumoto A, Ihara K, Shimizu M, Kyogoku Y, Ogawa N, Oshima Y, Hakoshima T (August 1997). "Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition". EMBO J. 16 (15): 4689–97. doi:10.1093/emboj/16.15.4689. PMC 1170095. PMID 9303313.
Berben G, Legrain M, Gilliquet V, Hilger F (1990). "The yeast regulatory gene PHO4 encodes a helix-loop-helix motif". Yeast. 6 (5): 451–4. doi:10.1002/yea.320060510. PMID 2220078.
Shao D, Creasy CL, Bergman LW (February 1998). "A cysteine residue in helixII of the bHLH domain is essential for homodimerization of the yeast transcription factor Pho4p". Nucleic Acids Res. 26 (3): 710–4. doi:10.1093/nar/26.3.710. PMC 147311. PMID 9443961.
Ogawa N, Oshima Y (May 1990). "Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae". Mol. Cell. Biol. 10 (5): 2224–36. doi:10.1128/mcb.10.5.2224. PMC 360570. PMID 2183025.

External links

PHO4+protein,+S+cerevisiae at the US National Library of Medicine Medical Subject Headings (MeSH)

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[pmid9303313-1] PDB: 1a0a; Shimizu T, Toumoto A, Ihara K, Shimizu M, Kyogoku Y, Ogawa N, Oshima Y, Hakoshima T (August 1997). "Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition". EMBO J. 16 (15): 4689–97. doi:10.1093/emboj/16.15.4689. PMC 1170095. PMID 9303313.

[pmid2220078-2] Berben G, Legrain M, Gilliquet V, Hilger F (1990). "The yeast regulatory gene PHO4 encodes a helix-loop-helix motif". Yeast. 6 (5): 451–4. doi:10.1002/yea.320060510. PMID 2220078.

[pmid9443961-3] Shao D, Creasy CL, Bergman LW (February 1998). "A cysteine residue in helixII of the bHLH domain is essential for homodimerization of the yeast transcription factor Pho4p". Nucleic Acids Res. 26 (3): 710–4. doi:10.1093/nar/26.3.710. PMC 147311. PMID 9443961.

[pmid2183025-4] Ogawa N, Oshima Y (May 1990). "Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae". Mol. Cell. Biol. 10 (5): 2224–36. doi:10.1128/mcb.10.5.2224. PMC 360570. PMID 2183025.