TCF15

Transcription factor 15 is a protein that in humans is encoded by the TCF15 gene. [5]

TCF15
Identifiers
Aliases	TCF15, EC2, PARAXIS, bHLHa40, transcription factor 15 (basic helix-loop-helix), transcription factor 15
External IDs	OMIM: 601010 MGI: 104664 HomoloGene: 37943 GeneCards: TCF15
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 603,797 bp[1] End 610,398 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 G3|2 74.83 cM Start 152,143,561 bp[2] End 152,149,097 bp[2]
Gene ontology Molecular function • DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • RNA polymerase II transcription factor complex Biological process • somitogenesis • respiratory system process • regulation of transcription, DNA-templated • muscle organ morphogenesis • eating behavior • neuromuscular process controlling posture • regulation of transcription from RNA polymerase II promoter • skeletal system morphogenesis • muscle organ development • ear development • transcription, DNA-templated • multicellular organism development • establishment of epithelial cell apical/basal polarity • regulation of extracellular matrix organization • post-anal tail morphogenesis • regulation of gene expression • mesoderm development • anterior/posterior pattern specification • skin development • paraxial mesoderm development • mesenchymal to epithelial transition • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6939	21407
Ensembl	ENSG00000125878	ENSMUSG00000068079
UniProt	Q12870	Q60756
RefSeq (mRNA)	NM_004609	NM_009328
RefSeq (protein)	NP_004600	NP_033354
Location (UCSC)	Chr 20: 0.6 – 0.61 Mb	Chr 2: 152.14 – 152.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008].

References

1. GRCh38: Ensembl release 89: ENSG00000125878 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068079 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Transcription factor 15". Retrieved 2017-11-09.

Further reading

• Guo P, Zhao KW, Dong XY, Sun X, Dong JT (2009). "Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells". J. Biol. Chem. 284 (27): 18184–93. doi:10.1074/jbc.M109.007096. PMC 2709394. PMID 19419955.
• Coppiello G, Collantes M, Sirerol-Piquer MS, Vandenwijngaert S, Schoors S, Swinnen M, Vandersmissen I, Herijgers P, Topal B, van Loon J, Goffin J, Prósper F, Carmeliet P, García-Verdugo JM, Janssens S, Peñuelas I, Aranguren XL, Luttun A (2015). "Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake". Circulation. 131 (9): 815–26. doi:10.1161/CIRCULATIONAHA.114.013721. PMID 25561514.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.