ELK3

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.[5][6]

ELK3
Identifiers
Aliases	ELK3, ERP, NET, SAP2, SAP-2, ETS transcription factor, ETS transcription factor ELK3
External IDs	OMIM: 600247 MGI: 101762 HomoloGene: 3833 GeneCards: ELK3
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.1 Start 96,194,375 bp[1] End 96,269,824 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C2|10 48.04 cM Start 93,247,414 bp[2] End 93,311,135 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948 protein binding • GO:0001106 transcription corepressor activity • purine-rich negative regulatory element binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component • mitochondrion • nucleoplasm • cytoplasm • cell nucleus Biological process • transcription, DNA-templated • cell differentiation • wound healing • regulation of transcription, DNA-templated • angiogenesis • signal transduction • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2004	13713
Ensembl	ENSG00000111145	ENSMUSG00000008398
UniProt	P41970	P41971
RefSeq (mRNA)	NM_001303511 NM_005230	NM_001282967 NM_013508 NM_205536 NM_001322265 NM_001322268
RefSeq (protein)	NP_001290440 NP_005221	NP_001269896 NP_001309194 NP_001309197 NP_038536
Location (UCSC)	Chr 12: 96.19 – 96.27 Mb	Chr 10: 93.25 – 93.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.[6]

Interactions

ELK3 has been shown to interact with TCF3.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000111145 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008398 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shipley J, Sheer D, Dalton S, Treisman R, Patel K (Mar 1995). "Mapping of the human SAP1 (SRF accessory protein 1) gene and SAP2, a gene encoding a related protein, to chromosomal bands 1q32 and 12q23, respectively". Genomics. 23 (3): 710–1. doi:10.1006/geno.1994.1564. PMID 7851904.
6. "Entrez Gene: ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)".
7. Maira, S M; Wurtz J M; Wasylyk B (Nov 1996). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. ENGLAND. 15 (21): 5849–65. doi:10.1002/j.1460-2075.1996.tb00972.x. ISSN 0261-4189. PMC 452333. PMID 8918463.

Further reading

• Sharrocks AD, Brown AL, Ling Y, Yates PR (1998). "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. doi:10.1016/S1357-2725(97)00086-1. PMID 9570133.
• Wasylyk B, Hagman J, Gutierrez-Hartmann A (1998). "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway". Trends Biochem. Sci. 23 (6): 213–6. doi:10.1016/S0968-0004(98)01211-0. PMID 9644975.
• Price MA, Rogers AE, Treisman R (1995). "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)". EMBO J. 14 (11): 2589–601. doi:10.1002/j.1460-2075.1995.tb07257.x. PMC 398373. PMID 7540136.
• Giovane A, Pintzas A, Maira SM, et al. (1994). "Net, a new ets transcription factor that is activated by Ras". Genes Dev. 8 (13): 1502–13. doi:10.1101/gad.8.13.1502. PMID 7958835.
• Maira SM, Wurtz JM, Wasylyk B (1997). "Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif". EMBO J. 15 (21): 5849–65. doi:10.1002/j.1460-2075.1996.tb00972.x. PMC 452333. PMID 8918463.
• Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B (1999). "Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation". EMBO J. 18 (12): 3392–403. doi:10.1093/emboj/18.12.3392. PMC 1171419. PMID 10369679.
• Ducret C, Maira SM, Dierich A, Wasylyk B (2000). "The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock". Mol. Cell. Biol. 19 (10): 7076–87. doi:10.1128/mcb.19.10.7076. PMC 84702. PMID 10490644.
• Ducret C, Maira SM, Lutz Y, Wasylyk B (2000). "The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades". Oncogene. 19 (44): 5063–72. doi:10.1038/sj.onc.1203892. PMID 11042694.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gupta M, Sueblinvong V, Raman J, et al. (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure". J. Biol. Chem. 278 (45): 44935–48. doi:10.1074/jbc.M307696200. PMID 12933792.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wasylyk C, Criqui-Filipe P, Wasylyk B (2005). "Sumoylation of the net inhibitory domain (NID) is stimulated by PIAS1 and has a negative effect on the transcriptional activity of Net". Oncogene. 24 (5): 820–8. doi:10.1038/sj.onc.1208226. PMID 15580297.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• ELK3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.