HLF (gene)

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[5][6]

HLF
Identifiers
AliasesHLF, PAR bZIP transcription factor, HLF transcription factor, PAR bZIP family member
External IDsOMIM: 142385 MGI: 96108 HomoloGene: 31074 GeneCards: HLF
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q22Start55,264,960 bp[1]
End55,325,187 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3131

217082

Ensembl

ENSG00000108924

ENSMUSG00000003949

UniProt

Q16534

Q8BW74

RefSeq (mRNA)

NM_002126
NM_001330375

NM_172563

RefSeq (protein)

NP_001317304
NP_002117

NP_766151

Location (UCSC)Chr 17: 55.26 – 55.33 MbChr 11: 90.34 – 90.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000108924 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003949 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (July 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science. 257 (5069): 531–4. Bibcode:1992Sci...257..531I. doi:10.1126/science.1386162. PMID 1386162.
  6. "Entrez Gene: HLF hepatic leukemia factor".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.