Hepatocyte nuclear factor 4 gamma

Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is encoded by the HNF4G gene.[5][6][7]

HNF4G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LV2
Identifiers
Aliases	HNF4G, NR2A2, NR2A3, Hepatocyte nuclear factor 4 gamma
External IDs	OMIM: 605966 MGI: 1353604 HomoloGene: 37886 GeneCards: HNF4G
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.13 Start 75,407,914 bp[1] End 75,566,834 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A1 Start 3,508,030 bp[2] End 3,658,052 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • steroid hormone receptor activity • sequence-specific DNA binding • DNA binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • zinc ion binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus • nucleoplasm Biological process • regulation of transcription from RNA polymerase II promoter • intracellular receptor signaling pathway • transcription initiation from RNA polymerase II promoter • regulation of transcription, DNA-templated • transcription, DNA-templated • steroid hormone mediated signaling pathway • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3174	30942
Ensembl	ENSG00000164749	ENSMUSG00000017688
UniProt	Q14541	Q9WUU6
RefSeq (mRNA)	NM_004133 NM_001330561	NM_013920
RefSeq (protein)	NP_001317490 NP_004124	NP_038948
Location (UCSC)	Chr 8: 75.41 – 75.57 Mb	Chr 3: 3.51 – 3.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Hepatocyte nuclear factor 4
• Hepatocyte nuclear factors

References

1. GRCh38: Ensembl release 89: ENSG00000164749 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000017688 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma".
6. Drewes T, Senkel S, Holewa B, Ryffel GU (March 1996). "Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes". Molecular and Cellular Biology. 16 (3): 925–31. doi:10.1128/mcb.16.3.925. PMC 231074. PMID 8622695.
7. Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM, Williams SP (September 2002). "Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids". Structure. 10 (9): 1225–34. doi:10.1016/S0969-2126(02)00829-8. PMID 12220494.

Further reading

• Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, Ryffel GU, Krolewski AS, Doria A (October 1999). "Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes". Diabetes. 48 (10): 2099–102. doi:10.2337/diabetes.48.10.2099. PMID 10512380.
• Ozeki T, Takahashi Y, Nakayama K, Funayama M, Nagashima K, Kodama T, Kamataki T (January 2003). "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers". Pharmacogenetics. 13 (1): 49–53. doi:10.1097/00008571-200301000-00007. PMID 12544512.

External links

• FactorBook HNF4G