Sp3 transcription factor

Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by.

SP3
Identifiers
Aliases	SP3, SPR2, Sp3 transcription factor
External IDs	OMIM: 601804 MGI: 1277166 HomoloGene: 7952 GeneCards: SP3
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 173,880,850 bp[1] End 173,965,702 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 72,936,427 bp[2] End 72,980,446 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • chromatin binding • GO:0001158 core promoter proximal region sequence-specific DNA binding • metal ion binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948 protein binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • double-stranded DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component • PML body • transcriptional repressor complex • cell nucleus • nucleoplasm • protein-DNA complex Biological process • megakaryocyte differentiation • regulation of transcription, DNA-templated • ossification • lung development • embryonic placenta development • in utero embryonic development • negative regulation of transcription from RNA polymerase II promoter • monocyte differentiation • protein sumoylation • transcription, DNA-templated • embryonic skeletal system development • positive regulation of transcription, DNA-templated • embryonic process involved in female pregnancy • T cell differentiation • granulocyte differentiation • embryonic camera-type eye morphogenesis • trophectodermal cell differentiation • enucleate erythrocyte differentiation • erythrocyte differentiation • definitive hemopoiesis • liver development • B cell differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • natural killer cell differentiation • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6670	20687
Ensembl	ENSG00000172845	ENSMUSG00000027109
UniProt	Q02447 Q86TP0	O70494
RefSeq (mRNA)	NM_003111 NM_001017371 NM_001172712	NM_001018042 NM_001098425 NM_011450
RefSeq (protein)	NP_001017371 NP_001166183 NP_003102 NP_003102.1	NP_001018052 NP_001091895
Location (UCSC)	Chr 2: 173.88 – 173.97 Mb	Chr 2: 72.94 – 72.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.[5]

Interactions

Sp3 transcription factor has been shown to interact with Histone deacetylase 2,[6][7] PIAS1,[8] E2F1[9] and GABPA.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000172845 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027109 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SP3 Sp3 transcription factor".
6. Won, Jaejoon; Yim Jeongbin; Kim Tae Kook (October 2002). "Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells". J. Biol. Chem. 277 (41): 38230–8. doi:10.1074/jbc.M206064200. ISSN 0021-9258. PMID 12151407.
7. Sun, Jian-Min; Chen Hou Yu; Moniwa Mariko; Litchfield David W; Seto Edward; Davie James R (September 2002). "The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2". J. Biol. Chem. 277 (39): 35783–6. doi:10.1074/jbc.C200378200. ISSN 0021-9258. PMID 12176973.
8. Sapetschnig, Alexandra; Rischitor Grigore; Braun Harald; Doll Andreas; Schergaut Marion; Melchior Frauke; Suske Guntram (October 2002). "Transcription factor Sp3 is silenced through SUMO modification by PIAS1". EMBO J. 21 (19): 5206–15. doi:10.1093/emboj/cdf510. ISSN 0261-4189. PMC 129032. PMID 12356736.
9. Rotheneder, H; Geymayer S; Haidweger E (November 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. ISSN 0022-2836. PMID 10547281.
10. Galvagni, F; Capo S; Oliviero S (March 2001). "Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter" (PDF). J. Mol. Biol. 306 (5): 985–96. doi:10.1006/jmbi.2000.4335. hdl:2318/141203. ISSN 0022-2836. PMID 11237613.

Further reading

• Tseng L, Gao J, Mazella J, et al. (1997). "Differentiation-dependent and cell-specific regulation of the hIGFBP-1 gene in human endometrium". Ann. N. Y. Acad. Sci. 828 (1): 27–37. Bibcode:1997NYASA.828...27T. doi:10.1111/j.1749-6632.1997.tb48521.x. PMID 9329821. S2CID 1601677.
• Zhang Y, Dufau ML (2003). "Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes". J. Steroid Biochem. Mol. Biol. 85 (2–5): 401–14. doi:10.1016/S0960-0760(03)00230-9. PMID 12943729. S2CID 28512341.