Sp2 transcription factor

Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.[5][6][7]

SP2
Identifiers
Aliases	SP2, Sp2, 4930480I16Rik, mKIAA0048, Sp2 transcription factor
External IDs	OMIM: 601801 MGI: 1926162 HomoloGene: 2340 GeneCards: SP2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 47,896,150 bp[1] End 47,928,957 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 96,953,341 bp[2] End 96,982,959 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • histone deacetylase binding • GO:0001948 protein binding • metal ion binding • nucleic acid binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • immune response • transcription, DNA-templated • multicellular organism growth • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6668	78912
Ensembl	ENSG00000167182	ENSMUSG00000018678
UniProt	Q02086 Q9BRW5	Q9D2H6
RefSeq (mRNA)	NM_003110	NM_001080964 NM_030220 NM_001363225 NM_001363226
RefSeq (protein)	NP_003101	NP_001074433 NP_084496 NP_001350154 NP_001350155
Location (UCSC)	Chr 17: 47.9 – 47.93 Mb	Chr 11: 96.95 – 96.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.[7]

Interactions

Sp2 transcription factor has been shown to interact with E2F1.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000167182 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018678 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kingsley C, Winoto A (October 1992). "Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression". Mol Cell Biol. 12 (10): 4251–61. doi:10.1128/mcb.12.10.4251. PMC 360348. PMID 1341900.
6. Scohy S, Van Vooren P, Szpirer C, Szpirer J (October 1998). "Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31→q32.1 (Sp2), 3q24→q31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3→q22 by in situ hybridization". Cytogenet Cell Genet. 81 (3–4): 273–4. doi:10.1159/000015044. PMID 9730617. S2CID 46786094.
7. "Entrez Gene: SP2 Sp2 transcription factor".
8. Rotheneder H, Geymayer S, Haidweger E (November 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281.

Further reading

• Philipsen S, Suske G (1999). "A tale of three fingers: the family of mammalian Sp/XKLF transcription factors". Nucleic Acids Res. 27 (15): 2991–3000. doi:10.1093/nar/27.15.2991. PMC 148522. PMID 10454592.
• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Rotheneder H, Geymayer S, Haidweger E (2000). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". J. Mol. Biol. 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281.
• Moorefield KS, Fry SJ, Horowitz JM (2004). "Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells". J. Biol. Chem. 279 (14): 13911–24. doi:10.1074/jbc.M313589200. PMID 14726517.
• Phan D, Cheng CJ, Galfione M, Vakar-Lopez F, Tunstead J, Thompson NE, Burgess RR, Najjar SM, Yu-Lee LY, Lin SH (2004). "Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis". Cancer Res. 64 (9): 3072–8. doi:10.1158/0008-5472.CAN-03-3730. PMID 15126343.
• Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, Robson SC, Europe-Finner GN (2005). "Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases". J. Clin. Endocrinol. Metab. 90 (6): 3479–90. doi:10.1210/jc.2004-1962. PMID 15788387.
• Lee YC, Higashi Y, Luu C, Shimizu C, Strott CA (2005). "Sp1 elements in SULT2B1b promoter and 5'-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition". FEBS Lett. 579 (17): 3639–45. doi:10.1016/j.febslet.2005.05.041. PMID 15953604. S2CID 22203267.
• Simmons SO, Horowitz JM (2006). "Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells". Biochem. J. 393 (Pt 1): 397–409. doi:10.1042/BJ20051030. PMC 1383699. PMID 16201967.
• Moorefield KS, Yin H, Nichols TD, Cathcart C, Simmons SO, Horowitz JM (2006). "Sp2 localizes to subnuclear foci associated with the nuclear matrix". Mol. Biol. Cell. 17 (4): 1711–22. doi:10.1091/mbc.E05-11-1063. PMC 1415311. PMID 16467376.
• Das A, Fernandez-Zapico ME, Cao S, Yao J, Fiorucci S, Hebbel RP, Urrutia R, Shah VH (2007). "Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration". J. Biol. Chem. 281 (51): 39105–13. doi:10.1074/jbc.M607720200. PMID 17071613.

External links

• Sp2+Transcription+Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook SP2