Excitatory amino acid transporter 4

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.[5][6]

SLC1A6
Identifiers
Aliases	SLC1A6, EAAT4, solute carrier family 1 member 6
External IDs	OMIM: 600637 MGI: 1096331 HomoloGene: 21055 GeneCards: SLC1A6
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.12 Start 14,950,034 bp[1] End 15,022,990 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 78,780,496 bp[2] End 78,814,765 bp[2]
Gene ontology Molecular function • L-aspartate transmembrane transporter activity • symporter activity • L-glutamate transmembrane transporter activity • amino acid transmembrane transporter activity • high-affinity glutamate transmembrane transporter activity • metal ion binding Cellular component • integral component of membrane • Golgi apparatus • membrane • intermediate filament cytoskeleton • integral component of plasma membrane • cell membrane • glutamatergic synapse • integral component of presynaptic membrane Biological process • chemical synaptic transmission • regulation of membrane potential • ion transport • glutamate secretion • aspartate transport • L-glutamate transport • L-glutamate import across plasma membrane • amino acid transport • L-aspartate transport • neurotransmitter uptake • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6511	20513
Ensembl	ENSG00000105143	ENSMUSG00000005357
UniProt	P48664	O35544
RefSeq (mRNA)	NM_001272087 NM_001272088 NM_005071	NM_009200
RefSeq (protein)	NP_001259016 NP_001259017 NP_005062	NP_033226
Location (UCSC)	Chr 19: 14.95 – 15.02 Mb	Chr 10: 78.78 – 78.81 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000105143 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005357 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)".
6. Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature. 375 (6532): 599–603. doi:10.1038/375599a0. PMID 7791878. S2CID 4334983.

Further reading

• Deng X, Shibata H, Takeuchi N, et al. (2007). "Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (3): 271–8. doi:10.1002/ajmg.b.30351. PMID 17221839. S2CID 42347750.
• Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMC 2986499. PMID 19156168.
• Poulsen MV, Vandenberg RJ (2001). "Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4". J. Physiol. 534 (Pt 1): 159–67. doi:10.1111/j.1469-7793.2001.00159.x. PMC 2278676. PMID 11432999.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Koch HP, Brown RL, Larsson HP (2007). "The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits". J. Neurosci. 27 (11): 2943–7. doi:10.1523/JNEUROSCI.0118-07.2007. PMC 2435202. PMID 17360917.
• Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins". Nature. 410 (6824): 89–93. doi:10.1038/35065091. PMID 11242047. S2CID 4381210.
• Rajamanickam J, Palmada M, Lang F, Boehmer C (2007). "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase". J. Neurochem. 102 (3): 858–66. doi:10.1111/j.1471-4159.2007.04585.x. PMID 17442044. S2CID 30779935.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824. S2CID 4420825.