Cationic amino acid transporter 2

Cationic amino acid transporter 2 is a protein that in humans is encoded by the SLC7A2 gene.[5][6]

SLC7A2
Identifiers
Aliases	SLC7A2, ATRC2, CAT2, HCAT2, solute carrier family 7 member 2
External IDs	OMIM: 601872 MGI: 99828 HomoloGene: 20659 GeneCards: SLC7A2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p22 Start 17,497,088 bp[1] End 17,570,573 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A4|8 23.89 cM Start 40,862,396 bp[2] End 40,922,308 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • high-affinity lysine transmembrane transporter activity • low-affinity L-arginine transmembrane transporter activity • GO:0015598 L-arginine transmembrane transporter activity • basic amino acid transmembrane transporter activity • high-affinity arginine transmembrane transporter activity • high-affinity L-ornithine transmembrane transporter activity • L-ornithine transmembrane transporter activity • arginine transmembrane transporter activity • L-lysine transmembrane transporter activity • amino acid transmembrane transporter activity • GO:0022891 transmembrane transporter activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • cell membrane • cell junction Biological process • arginine transport • nitric oxide biosynthetic process • cellular amino acid metabolic process • nitric oxide production involved in inflammatory response • L-arginine transport • regulation of inflammatory response • L-lysine import across plasma membrane • L-arginine import across plasma membrane • L-ornithine import across plasma membrane • macrophage activation • L-ornithine transmembrane transport • amino acid transport • regulation of macrophage activation • transmembrane transport • L-lysine transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6542	11988
Ensembl	ENSG00000003989	ENSMUSG00000031596
UniProt	P52569	P18581
RefSeq (mRNA)	NM_001008539 NM_001164771 NM_003046 NM_001370337 NM_001370338	NM_001044740 NM_007514
RefSeq (protein)	NP_001008539 NP_001158243 NP_003037 NP_001357266 NP_001357267	NP_001038205 NP_031540
Location (UCSC)	Chr 8: 17.5 – 17.57 Mb	Chr 8: 40.86 – 40.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• SLC7A2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

References

1. GRCh38: Ensembl release 89: ENSG00000003989 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031596 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hoshide R, Ikeda Y, Karashima S, Matsuura T, Komaki S, Kishino T, Niikawa N, Endo F, Matsuda I (Mar 1997). "Molecular cloning, tissue distribution, and chromosomal localization of human cationic amino acid transporter 2 (HCAT2)". Genomics. 38 (2): 174–8. doi:10.1006/geno.1996.0613. PMID 8954799.
6. "Entrez Gene: SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• González M, Flores C, Pearson JD, et al. (2005). "Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells". Pflügers Arch. 448 (4): 383–94. doi:10.1007/s00424-004-1261-x. PMID 15064952. S2CID 25238852.
• Schnorr O, Suschek CV, Kolb-Bachofen V (2003). "The importance of cationic amino acid transporter expression in human skin". J. Invest. Dermatol. 120 (6): 1016–22. doi:10.1046/j.1523-1747.2003.12139.x. PMID 12787129.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hammermann R, Brunn G, Racké K (2002). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4". Amino Acids. 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818. S2CID 30892800.
• Closs EI, Gräf P, Habermeier A, et al. (1997). "Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties". Biochemistry. 36 (21): 6462–8. doi:10.1021/bi962829p. PMID 9174363.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.