Lotilaner

Lotilaner (INN; trade name Credelio) is a veterinary drug used to control fleas and ticks in dogs.[1] It is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and for the treatment and control of tick infestations including lone star tick (Amblyomma americanum), American dog tick (Dermacentor variabilis), black-legged tick (Ixodes scapularis), and brown dog tick (Rhipicephalus sanguineus).[2]

Lotilaner

Clinical data
Trade names	Credelio
Legal status
Legal status	EU: Rx-only
Identifiers
IUPAC name 3-Methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide
CAS Number	1369852-71-0
PubChem CID	76959255
ChemSpider	32699771
UNII	HEH4938D7K
KEGG	D11212
ChEMBL	ChEMBL3707310
Chemical and physical data
Formula	C20H14Cl3F6N3O3S
Molar mass	596.75 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

References

1. Kuntz EA, Kammanadiminti S (November 2017). "Safety evaluation of lotilaner in dogs after oral administration as flavoured chewable tablets (Credelio™)". Parasites & Vectors. 10 (1): 538. doi:10.1186/s13071-017-2468-y. PMC 5664904. PMID 29089043.
2. "FREEDOM OF INFORMATION SUMMARY, SUPPLEMENTAL NEW ANIMAL DRUG APPLICATION, NADA 141-494, Credelio, Lotilaner, Chewable Tablets, Dogs". September 3, 2019.