DFDT

Difluorodiphenyltrichloroethane (DFDT) is a chemical compound. Its composition is the same as that of the insecticide DDT, except that two of DDT's chlorine atoms are replaced by two fluorine atoms.[1]

DFDT

Names
IUPAC name 1-Fluoro-4-[2,2,2-trichloro-1-(4-fluorophenyl)ethyl]benzene
Other names Fluorogesarol; Fluoro-DDT; p,p′-Fluoro-DDT; p,p′-Difluorodiphenyltrichloroethane
Identifiers
CAS Number	475-26-3
3D model (JSmol)	Interactive image
ChemSpider	9733
ECHA InfoCard	100.006.814
EC Number	207-493-3
PubChem CID	10139
UNII	5OLW69O0Q3
CompTox Dashboard (EPA)	DTXSID9042253
InChI InChI=1S/C14H9Cl3F2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13H Key: CLSXNIPAOWPLFR-UHFFFAOYSA-N
SMILES C1=CC(=CC=C1C(C2=CC=C(C=C2)F)C(Cl)(Cl)Cl)F
Properties
Chemical formula	C14H9Cl3F2
Molar mass	321.57 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

DFDT was developed as an insecticide by German scientists during World War II, partly to avoid having to pay license fees for DDT. It was documented by Allied military intelligence, but remained in obscurity after the war.[1]

In 2019, New York University chemists reported that DFDT and a mono-fluorinated derivative, MFDT, might be a more effective insecticide than DDT, and might therefore be used to combat malaria with less of an environmental impact.[1][2] A later study, however, found that "DFDT is unlikely to be a viable public health vector control insecticide".[3]

References

1. Chang, Kenneth (17 October 2019). "A Nazi Version of DDT Was Forgotten. Could It Help Fight Malaria?". The New York Times. Retrieved 18 October 2019.
2. Zhu, Xiaolong; Hu, Chunhua T.; Yang, Jingxiang; Joyce, Leo A.; Qiu, Mengdi; Ward, Michael D.; Kahr, Bart (11 October 2019). "Manipulating Solid Forms of Contact Insecticides for Infectious Disease Prevention". Journal of the American Chemical Society. doi:10.1021/jacs.9b08125.
3. Norris, Edmund J.; Demares, Fabien; Zhu, Xiaolong; Bloomquist, Jeffrey R. (2020-11-01). "Mosquitocidal activity of p,p'-difluoro-diphenyl-trichloroethane (DFDT)". Pesticide Biochemistry and Physiology. 170: 104686. doi:10.1016/j.pestbp.2020.104686. ISSN 0048-3575.