Hydramethylnon

Hydramethylnon is an organic chemical compound. It is also known as AC 217,300. It is in a chemical class called trifluoromethyl aminohydrazone, which is a metabolic inhibitor. It is classified as a pesticide designed to control insects that are harmful to humans.[1] It works by inhibiting complex III in the mitochondrial inner membrane and leads to a halting of oxidative phosphorylation. It is used primarily as an insecticide in the form of baits for cockroaches and ants.[2] Some brands of insecticides that include hydramethylnon are Amdro, Combat, Blatex, Cyaforce, Cyclon, Faslane, Grant's, Impact, Matox, Maxforce, Pyramdron, Siege, Scuttle and Wipeout. Hydramethylnon is a slow-acting poison with delayed toxicity that needs to be eaten to be effective.[3]

Hydramethylnon
Names
IUPAC name
2(1H)-pyrimidinone, tetrahydro-5,5-dimethyl-,

(3-(4-(trifluoromethyl)phenyl) -1-(2-(4-(trifluoromethyl)phenyl)ethenyl)

-2-propenylidene)hydrazone
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.100.669
KEGG
UNII
Properties
C25H24F6N4
Molar mass 494.485 g·mol−1
Appearance Yellow to orange crystalline solid
Melting point 185 to 190 °C (365 to 374 °F; 458 to 463 K)
Hazards
NFPA 704 (fire diamond)
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilHealth code 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineReactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no code
1
1
0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Toxicology

Hydramethylnon has low toxicity to mammals.[2][3] The oral LD50 is 1100–1300 mg/kg in rats and above 28,000 mg/kg in dogs.[3] Hydramethylnon is toxic to fish; the 96-hour LC50 in rainbow trout is 0.16 mg/L, 0.10 mg/L in channel catfish, and 1.70 mg/L in bluegill sunfish.

Hydramethylnon, when fed to rats for two years led to an increase in uterine and adrenal tumors at the highest dose; therefore, the Environmental Protection Agency classifies hydramethylnon as a possible human carcinogen.[3]

See also
  • Fipronil, another insecticide used for similar purposes

References
  1. "Hydramethylnon". PubChem.
  2. Veterinary Support Personnel Network
  3. "Hydramethylnon" (PDF). National Pesticide Information Center.
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