IRAK3

Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene.[5][6] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance and repair of endothelial barrier after endotoxin-induced lung injury.[7]

IRAK3
Identifiers
Aliases	IRAK3, ASRT5, IRAKM, interleukin 1 receptor associated kinase 3
External IDs	OMIM: 604459 MGI: 1921164 HomoloGene: 36215 GeneCards: IRAK3
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.3 Start 66,189,195 bp[1] End 66,254,622 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 120,141,648 bp[2] End 120,202,130 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • protein kinase activity • transferase activity • magnesium ion binding • protein serine/threonine kinase activity • kinase activity • protein homodimerization activity • protein heterodimerization activity • ATP binding • GO:0001948 protein binding Cellular component • cytoplasm • cell nucleus • cell membrane Biological process • response to lipopolysaccharide • negative regulation of innate immune response • signal transduction • negative regulation of macrophage cytokine production • autophosphorylation • negative regulation of protein complex disassembly • response to interleukin-1 • response to exogenous dsRNA • protein phosphorylation • negative regulation of toll-like receptor signaling pathway • cytokine-mediated signaling pathway • response to virus • response to peptidoglycan • negative regulation of cytokine-mediated signaling pathway • regulation of protein complex disassembly • positive regulation of macrophage tolerance induction • negative regulation of NF-kappaB transcription factor activity • phosphorylation • negative regulation of protein catabolic process • negative regulation of interleukin-6 production • interleukin-1-mediated signaling pathway • positive regulation of NF-kappaB transcription factor activity • negative regulation of MAP kinase activity • negative regulation of tumor necrosis factor production • negative regulation of interleukin-12 production • MyD88-dependent toll-like receptor signaling pathway • GO:0007243 intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11213	73914
Ensembl	ENSG00000090376	ENSMUSG00000020227
UniProt	Q9Y616	Q8K4B2
RefSeq (mRNA)	NM_007199 NM_001142523	NM_028679 NM_001359184
RefSeq (protein)	NP_001135995 NP_009130	NP_082955 NP_001346113
Location (UCSC)	Chr 12: 66.19 – 66.25 Mb	Chr 10: 120.14 – 120.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000090376 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020227 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (July 1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". The Journal of Biological Chemistry. 274 (27): 19403–10. doi:10.1074/jbc.274.27.19403. PMID 10383454.
6. "Entrez Gene: IRAK3 interleukin-1 receptor-associated kinase 3".
7. Soni D, Wang DM, Regmi SC, Mittal M, Vogel SM, Schlüter D, Tiruppathi C (May 2018). "Deubiquitinase function of A20 maintains and repairs endothelial barrier after lung vascular injury". Cell Death Discovery. 4 (60): 60. doi:10.1038/s41420-018-0056-3. PMC 5955943. PMID 29796309.

Further reading

• Rosati O, Martin MU (May 2002). "Identification and characterization of murine IRAK-M". Biochemical and Biophysical Research Communications. 293 (5): 1472–7. doi:10.1016/S0006-291X(02)00411-4. PMID 12054681.
• Bin LH, Xu LG, Shu HB (July 2003). "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling". The Journal of Biological Chemistry. 278 (27): 24526–32. doi:10.1074/jbc.M303451200. PMID 12721283.
• Escoll P, del Fresno C, García L, Vallés G, Lendínez MJ, Arnalich F, López-Collazo E (November 2003). "Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients". Biochemical and Biophysical Research Communications. 311 (2): 465–72. doi:10.1016/j.bbrc.2003.10.019. PMID 14592437.
• del Fresno C, Otero K, Gómez-García L, González-León MC, Soler-Ranger L, Fuentes-Prior P, Escoll P, Baos R, Caveda L, García F, Arnalich F, López-Collazo E (March 2005). "Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4". Journal of Immunology. 174 (5): 3032–40. doi:10.4049/jimmunol.174.5.3032. PMID 15728517.
• Su J, Xie Q, Wilson I, Li L (July 2007). "Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling". Cellular Signalling. 19 (7): 1596–601. doi:10.1016/j.cellsig.2007.02.009. PMC 1978187. PMID 17379480.
• Balaci L, Spada MC, Olla N, Sole G, Loddo L, Anedda F, Naitza S, Zuncheddu MA, Maschio A, Altea D, Uda M, Pilia S, Sanna S, Masala M, Crisponi L, Fattori M, Devoto M, Doratiotto S, Rassu S, Mereu S, Giua E, Cadeddu NG, Atzeni R, Pelosi U, Corrias A, Perra R, Torrazza PL, Pirina P, Ginesu F, Marcias S, Schintu MG, Del Giacco GS, Manconi PE, Malerba G, Bisognin A, Trabetti E, Boner A, Pescollderungg L, Pignatti PF, Schlessinger D, Cao A, Pilia G (June 2007). "IRAK-M is involved in the pathogenesis of early-onset persistent asthma". American Journal of Human Genetics. 80 (6): 1103–14. doi:10.1086/518259. PMC 1867098. PMID 17503328.
• Weersma RK, Oostenbrug LE, Nolte IM, Van Der Steege G, Oosterom E, Van Dullemen HM, Kleibeuker JH, Dijkstra G (July 2007). "Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases". Scandinavian Journal of Gastroenterology. 42 (7): 827–33. doi:10.1080/00365520601114024. PMID 17558906. S2CID 22703718.
• van 't Veer C, van den Pangaart PS, van Zoelen MA, de Kruif M, Birjmohun RS, Stroes ES, de Vos AF, van der Poll T (November 2007). "Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model". Journal of Immunology. 179 (10): 7110–20. doi:10.4049/jimmunol.179.10.7110. PMID 17982103.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9Y616 (Interleukin-1 receptor-associated kinase 3) at the PDBe-KB.