IFNA6

Interferon alpha-6 is a protein that in humans is encoded by the IFNA6 gene.[3][4]

IFNA6
Identifiers
Aliases	IFNA6, IFN-alphaK, interferon alpha 6
External IDs	OMIM: 147566 HomoloGene: 105727 GeneCards: IFNA6
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.3 Start 21,349,835 bp[1] End 21,351,378 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine activity • type I interferon receptor binding • cytokine receptor binding Cellular component • extracellular region • extracellular • cellular component Biological process • natural killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • blood coagulation • positive regulation of peptidyl-serine phosphorylation of STAT protein • humoral immune response • adaptive immune response • defense response to virus • type I interferon signaling pathway • response to exogenous dsRNA • T cell activation involved in immune response • cytokine-mediated signaling pathway • innate immune system • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3443	n/a
Ensembl	ENSG00000120235	n/a
UniProt	P05013	n/a
RefSeq (mRNA)	NM_021002	n/a
RefSeq (protein)	NP_066282	n/a
Location (UCSC)	Chr 9: 21.35 – 21.35 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000120235 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
4. "Entrez Gene: IFNA6 interferon, alpha 6".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Hardy MP, Owczarek CM, Jermiin LS, et al. (2005). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329. ( Pt 2) (2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.