EIF2AK4

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.[5][6]

EIF2AK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UKX, 4OTN
Identifiers
Aliases	EIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4
External IDs	OMIM: 609280 MGI: 1353427 HomoloGene: 40891 GeneCards: EIF2AK4
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 39,934,115 bp[1] End 40,035,591 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 118,388,618 bp[2] End 118,475,234 bp[2]
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • tRNA binding • kinase activity • protein serine/threonine kinase activity • RNA binding • ATP binding • eukaryotic translation initiation factor 2alpha kinase activity Cellular component • cytoplasm • polysome • cytosolic ribosome Biological process • positive regulation of translational initiation in response to starvation • adaptive immune response • negative regulation of neuron differentiation • positive regulation of long-term synaptic potentiation • positive regulation of adaptive immune response • negative regulation of translational initiation in response to stress • negative regulation of translational initiation • phosphorylation • immune system process • cellular response to UV • cellular response to amino acid starvation • negative regulation of CREB transcription factor activity • regulation of feeding behavior • learning • nervous system development • viral translation • neuron projection extension • protein phosphorylation • cellular response to cold • long-term memory • defense response to virus • cellular response to leucine starvation • cell cycle arrest • regulation of eIF2 alpha phosphorylation by amino acid starvation • eiF2alpha phosphorylation in response to endoplasmic reticulum stress • induction by virus of host autophagy • autophosphorylation • cell cycle • negative regulation by host of viral genome replication • GO:0022415 viral process • regulation of translation • regulation of translational initiation • positive regulation of defense response to virus by host • T cell activation involved in immune response • DNA damage checkpoint • regulation of translational initiation by eIF2 alpha phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	440275	27103
Ensembl	ENSG00000128829	ENSMUSG00000005102
UniProt	Q9P2K8	Q9QZ05
RefSeq (mRNA)	NM_001013703	NM_001177806 NM_013719 NM_001355383
RefSeq (protein)	NP_001013725	NP_001171277 NP_038747 NP_001342312
Location (UCSC)	Chr 15: 39.93 – 40.04 Mb	Chr 2: 118.39 – 118.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM][6]

See also

• Gcn2

References

1. GRCh38: Ensembl release 89: ENSG00000128829 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005102 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem. 265 (2): 754–62. doi:10.1046/j.1432-1327.1999.00780.x. PMID 10504407.
6. "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4".

Further reading

• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry" (PDF). Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9P2K8 (eIF-2-alpha kinase GCN2) at the PDBe-KB.