PSKH1

Serine/threonine-protein kinase H1 is an enzyme that in humans is encoded by the PSKH1 gene.[5][6]

PSKH1
Identifiers
Aliases	PSKH1, protein serine kinase H1
External IDs	OMIM: 177015 MGI: 3528383 HomoloGene: 48461 GeneCards: PSKH1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,893,254 bp[1] End 67,929,676 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 105,900,441 bp[2] End 105,931,778 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • GO:0001948 protein binding • ATP binding • protein serine/threonine kinase activity Cellular component • cytoplasm • Golgi apparatus • nuclear speck • endoplasmic reticulum membrane • membrane • cell membrane • microtubule organizing center • endoplasmic reticulum • cytoskeleton • cell nucleus • intracellular • nucleoplasm • cellular component Biological process • phosphorylation • protein phosphorylation • heart development • determination of left/right symmetry • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • GO:0007243 intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5681	244631
Ensembl	ENSG00000159792	ENSMUSG00000048310
UniProt	P11801	Q91YA2
RefSeq (mRNA)	NM_006742	NM_173432
RefSeq (protein)	NP_006733	NP_775608
Location (UCSC)	Chr 16: 67.89 – 67.93 Mb	Chr 8: 105.9 – 105.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PSKH1 has been shown to interact with CDC6.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000159792 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048310 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Larsen F, Solheim J, Kristensen T, Kolstø AB, Prydz H (February 1994). "A tight cluster of five unrelated human genes on chromosome 16q22.1". Hum Mol Genet. 2 (10): 1589–95. doi:10.1093/hmg/2.10.1589. PMID 8268911.
6. "Entrez Gene: PSKH1 protein serine kinase H1".
7. Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (January 1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. 18 (2): 396–410. doi:10.1093/emboj/18.2.396. PMC 1171134. PMID 9889196.

Further reading

• Hanks SK (1987). "Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family". Proc. Natl. Acad. Sci. U.S.A. 84 (2): 388–92. doi:10.1073/pnas.84.2.388. PMC 304212. PMID 2948189.
• Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K (1999). "Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization". EMBO J. 18 (2): 396–410. doi:10.1093/emboj/18.2.396. PMC 1171134. PMID 9889196.
• Amarzguioui M, Brede G, Babaie E, Grotli M, Sproat B, Prydz H (2000). "Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymes". Nucleic Acids Res. 28 (21): 4113–24. doi:10.1093/nar/28.21.4113. PMC 113158. PMID 11058107.
• Brede G, Solheim J, Tröen G, Prydz H (2001). "Characterization of PSKH1, a novel human protein serine kinase with centrosomal, golgi, and nuclear localization". Genomics. 70 (1): 82–92. doi:10.1006/geno.2000.6365. PMID 11087665.
• Brede G, Solheim J, Prydz H (2002). "PSKH1, a novel splice factor compartment-associated serine kinase". Nucleic Acids Res. 30 (23): 5301–9. doi:10.1093/nar/gkf648. PMC 137962. PMID 12466556.
• Brede G, Solheim J, Stang E, Prydz H (2004). "Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus". Exp. Cell Res. 291 (2): 299–312. doi:10.1016/j.yexcr.2003.07.009. PMID 14644153.