MAP3K13

Mitogen-activated protein kinase kinase kinase 13 is an enzyme that in humans is encoded by the MAP3K13 gene.[5][6]

MAP3K13
Identifiers
Aliases	MAP3K13, LZK, MEKK13, MLK, mitogen-activated protein kinase kinase kinase 13
External IDs	OMIM: 604915 MGI: 2444243 HomoloGene: 37958 GeneCards: MAP3K13
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.2 Start 185,282,941 bp[1] End 185,489,094 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B1 Start 21,794,346 bp[2] End 21,933,439 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • protein homodimerization activity • identical protein binding • kinase activity • MAP kinase kinase kinase activity • protein serine/threonine kinase activity • protein kinase activity • ATP binding • protein kinase binding • metal ion binding • nucleotide binding • transferase activity • JUN kinase kinase kinase activity • IkappaB kinase complex binding • enzyme binding Cellular component • membrane • cytoplasm • IkappaB kinase complex Biological process • phosphorylation • activation of MAPKK activity • JNK cascade • protein phosphorylation • autophosphorylation • positive regulation of NF-kappaB transcription factor activity • MAPK cascade • activation of JNKK activity • activation of JUN kinase activity • positive regulation of neuron maturation • peptidyl-serine phosphorylation • positive regulation of axon extension • positive regulation of neuron projection arborization • positive regulation of branching morphogenesis of a nerve Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9175	71751
Ensembl	ENSG00000073803	ENSMUSG00000033618
UniProt	O43283	Q1HKZ5
RefSeq (mRNA)	NM_001242314 NM_001242317 NM_004721	NM_172821
RefSeq (protein)	NP_001229243 NP_001229246 NP_004712	NP_766409
Location (UCSC)	Chr 3: 185.28 – 185.49 Mb	Chr 16: 21.79 – 21.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.[6]

Interactions

MAP3K13 has been shown to interact with PRDX3.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000073803 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033618 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sakuma H, Ikeda A, Oka S, Kozutsumi Y, Zanetta JP, Kawasaki T (Dec 1997). "Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain". J Biol Chem. 272 (45): 28622–9. doi:10.1074/jbc.272.45.28622. PMID 9353328.
6. "Entrez Gene: MAP3K13 mitogen-activated protein kinase kinase kinase 13".
7. Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (Jan 2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477.

Further reading

• Masaki M, Ikeda A, Shiraki E, Oka S, Kawasaki T (2003). "Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically". Eur. J. Biochem. 270 (1): 76–83. doi:10.1046/j.1432-1033.2003.03363.x. PMID 12492477.
• Ikeda A, Sakuma H, Masaki M, Kozutsumi Y, Oka S, Inazawa J, Kawasaki T (2002). "Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene". J. Biochem. Mol. Biol. Biophys. 6 (2): 113–7. doi:10.1080/10258140290027243. PMID 12186766.
• Ikeda A, Hasegawa K, Masaki M, Moriguchi T, Nishida E, Kozutsumi Y, Oka S, Kawasaki T (2002). "Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway". J. Biochem. 130 (6): 773–81. doi:10.1093/oxfordjournals.jbchem.a003048. PMID 11726277.
• Ikeda A, Masaki M, Kozutsumi Y, Oka S, Kawasaki T (2001). "Identification and characterization of functional domains in a mixed lineage kinase LZK". FEBS Lett. 488 (3): 190–5. doi:10.1016/S0014-5793(00)02432-7. PMID 11163770. S2CID 44379847.
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.