STK19

Serine/threonine-protein kinase 19 is an enzyme that in humans is encoded by the STK19 gene.[5][6][7]

STK19
Identifiers
Aliases	STK19, D6S60, D6S60E, G11, HLA-RP1, RP1, serine/threonine kinase 19
External IDs	OMIM: 604977 MGI: 1860085 HomoloGene: 10449 GeneCards: STK19
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,971,091 bp[1] End 31,982,821 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 34,823,993 bp[2] End 34,836,945 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein serine/threonine kinase activity • ATP binding • kinase activity • GO:0001948 protein binding Cellular component • cell nucleus • nuclear speck Biological process • protein phosphorylation • phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8859	54402
Ensembl	ENSG00000226257 ENSG00000206342 ENSG00000236250 ENSG00000226033 ENSG00000204344 ENSG00000234947	ENSMUSG00000061207
UniProt	P49842	Q9JHN8
RefSeq (mRNA)	NM_004197 NM_032454	NM_019442
RefSeq (protein)	NP_004188 NP_115830	NP_062315
Location (UCSC)	Chr 6: 31.97 – 31.98 Mb	Chr 17: 34.82 – 34.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants.[7] The STK19 gene encodes a 29kDa protein that is tightly bound to chromatin in Hela cells. There is still debate as to whether this protein, when mutated, may be involved in the onset of NRAS melanomas, as the D89N mutation appears to be outside the coding region. [8]

References

1. ENSG00000206342, ENSG00000236250, ENSG00000226033, ENSG00000204344, ENSG00000234947 GRCh38: Ensembl release 89: ENSG00000226257, ENSG00000206342, ENSG00000236250, ENSG00000226033, ENSG00000204344, ENSG00000234947 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061207 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sargent CA, Anderson MJ, Hsieh SL, Kendall E, Gomez-Escobar N, Campbell RD (Jul 1994). "Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex". Hum Mol Genet. 3 (3): 481–8. doi:10.1093/hmg/3.3.481. PMID 8012361.
6. Gomez-Escobar N, Chou CF, Lin WW, Hsieh SL, Campbell RD (Dec 1998). "The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase". J Biol Chem. 273 (47): 30954–60. doi:10.1074/jbc.273.47.30954. PMID 9812991.
7. "Entrez Gene: STK19 serine/threonine kinase 19".
8. "Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver". doi:10.1016/j.cell.2020.04.014. Cite journal requires |journal= (help)

Further reading

• Yu CY (1991). "The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene". J. Immunol. 146 (3): 1057–66. PMID 1988494.
• Shen L, Wu LC, Sanlioglu S, et al. (1994). "Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication". J. Biol. Chem. 269 (11): 8466–76. PMID 8132574.
• Ulgiati D, Townend DC, Christiansen FT, et al. (1996). "Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype". Immunogenetics. 43 (4): 250–2. doi:10.1007/s002510050059. PMID 8575831.
• Yang Z, Shen L, Dangel AW, et al. (1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Wadle A, Mischo A, Henrich PP, et al. (2005). "Characterization of Hap/BAG-1 variants as RP1 binding proteins with antiapoptotic activity". Int. J. Cancer. 117 (6): 896–904. doi:10.1002/ijc.21259. PMID 15986447. S2CID 36464436.