TRPM4

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.[5][6]

TRPM4
Identifiers
Aliases	TRPM4, PFHB1B, TRPM4B, LTrpC4, htransient receptor potential cation channel subfamily M member 4, EKVP6
External IDs	OMIM: 606936 MGI: 1915917 HomoloGene: 23033 GeneCards: TRPM4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,157,741 bp[1] End 49,211,836 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 45,302,632 bp[2] End 45,333,780 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • calcium channel activity • calmodulin binding • ion channel activity • ATP binding • sodium channel activity • calcium activated cation channel activity • calcium ion binding • metal ion binding Cellular component • integral component of membrane • Golgi apparatus • membrane • cell membrane • nucleoplasm • endoplasmic reticulum • cytosol • neuronal cell body • sodium channel complex • spanning component of plasma membrane • spanning component of membrane Biological process • adaptive immune response • vasoconstriction • immune system process • positive regulation of canonical Wnt signaling pathway • regulation of membrane potential • cation transport • ion transport • protein sumoylation • dendritic cell chemotaxis • regulation of T cell cytokine production • cardiac conduction • positive regulation of cell proliferation • calcium ion transport • negative regulation of bone mineralization • positive regulation of atrial cardiac muscle cell action potential • positive regulation of heart rate • transmembrane transport • positive regulation of adipose tissue development • positive regulation of cytosolic calcium ion concentration • calcium ion transmembrane transport • positive regulation of fat cell differentiation • positive regulation of insulin secretion involved in cellular response to glucose stimulus • negative regulation of osteoblast differentiation • positive regulation of vasoconstriction • positive regulation of regulation of vascular smooth muscle cell membrane depolarization • ion transmembrane transport • calcium-mediated signaling • membrane depolarization during AV node cell action potential • membrane depolarization during Purkinje myocyte cell action potential • membrane depolarization during bundle of His cell action potential • regulation of heart rate by cardiac conduction • sodium ion import across plasma membrane • regulation of ventricular cardiac muscle cell action potential • protein homotetramerization • cellular response to ATP • inorganic cation transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54795	68667
Ensembl	ENSG00000130529	ENSMUSG00000038260
UniProt	Q8TD43	Q7TN37
RefSeq (mRNA)	NM_001195227 NM_017636 NM_001321281 NM_001321282 NM_001321283 NM_001321285	NM_175130
RefSeq (protein)	NP_001182156 NP_001308210 NP_001308211 NP_001308212 NP_001308214 NP_060106	NP_780339
Location (UCSC)	Chr 19: 49.16 – 49.21 Mb	Chr 7: 45.3 – 45.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

TRPM4 Channel Blocker

• 9-Phenanthrol

See also

• TRPM

References

1. GRCh38: Ensembl release 89: ENSG00000130529 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038260 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu XZ, Moebius F, Gill DL, Montell C (September 2001). "Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform". Proc. Natl. Acad. Sci. U.S.A. 98 (19): 10692–7. doi:10.1073/pnas.191360198. PMC 58528. PMID 11535825.
6. Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

Further reading

• Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
• Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP (2002). "TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization". Cell. 109 (3): 397–407. doi:10.1016/S0092-8674(02)00719-5. PMID 12015988. S2CID 14411824.
• Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP (2004). "TRPM4 regulates calcium oscillations after T cell activation". Science. 306 (5700): 1374–1377. doi:10.1126/science.1098845. PMID 15550671. S2CID 16459097.
• Vennekens R, Nilius B (2007). "Insights into TRPM4 function, regulation and physiological role". Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 179 (179): 269–85. doi:10.1007/978-3-540-34891-7_16. ISBN 978-3-540-34889-4. PMID 17217063.
• Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M (2007). "Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4" (PDF). Nat Immunol. 8 (3): 312–320. doi:10.1038/ni1441. PMID 17293867. S2CID 29303898.
• Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P (2008). "The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells". Nat Immunol. 9 (10): 1148–56. doi:10.1038/ni.1648. PMC 2956271. PMID 18758465.

External links

• TRPM4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.