KCNK10

Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K_2P10.1, is a potassium channel containing two pore-forming P domains.[5][6][7]

KCNK10
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4BW5, 4XDJ, 4XDK, 4XDL
Identifiers
Aliases	KCNK10, K2p10.1, PPP1R97, TREK-2, TREK2, potassium two pore domain channel subfamily K member 10
External IDs	OMIM: 605873 MGI: 1919508 HomoloGene: 11321 GeneCards: KCNK10
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q31.3 Start 88,180,103 bp[1] End 88,326,907 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 98,429,437 bp[2] End 98,578,310 bp[2]
Gene ontology Molecular function • potassium channel activity • voltage-gated ion channel activity • potassium ion leak channel activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • memory • ion transport • signal transduction • stabilization of membrane potential • potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54207	72258
Ensembl	ENSG00000100433	ENSMUSG00000033854
UniProt	P57789	n/a
RefSeq (mRNA)	NM_021161 NM_138317 NM_138318	NM_029911 NM_001316664 NM_001316665 NM_001316666
RefSeq (protein)	NP_066984 NP_612190 NP_612191	n/a
Location (UCSC)	Chr 14: 88.18 – 88.33 Mb	Chr 12: 98.43 – 98.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000100433 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033854 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000). "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors". The Journal of Biological Chemistry. 275 (37): 28398–405. doi:10.1074/jbc.M002822200. PMID 10880510.
6. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacological Reviews. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
7. Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (March 2015). "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac". Science. 347 (6227): 1256–9. doi:10.1126/science.1261512. PMC 6034649. PMID 25766236.

Further reading

• Gu W, Schlichthörl G, Hirsch JR, Engels H, Karschin C, Karschin A, Derst C, Steinlein OK, Daut J (March 2002). "Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2". The Journal of Physiology. 539 (Pt 3): 657–68. doi:10.1113/jphysiol.2001.013432. PMC 2290188. PMID 11897838.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nature Reviews. Neuroscience. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
• Gierten J, Ficker E, Bloehs R, Schlömer K, Kathöfer S, Scholz E, Zitron E, Kiesecker C, Bauer A, Becker R, Katus HA, Karle CA, Thomas D (August 2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". British Journal of Pharmacology. 154 (8): 1680–90. doi:10.1038/bjp.2008.213. PMC 2518462. PMID 18516069.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Bang H, Kim Y, Kim D (June 2000). "TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family". The Journal of Biological Chemistry. 275 (23): 17412–9. doi:10.1074/jbc.M000445200. PMID 10747911.

External links

• KCNK10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)