KCNC2

KCNC2
Identifiers
Aliases	KCNC2, KV3.2, potassium voltage-gated channel subfamily C member 2
External IDs	OMIM: 176256 MGI: 96668 HomoloGene: 71199 GeneCards: KCNC2
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	75,209,868 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	112,467,024 bp[2]
Gene ontology
Molecular function	• potassium channel activity; • ion channel binding; • voltage-gated ion channel activity; • ion channel activity; • voltage-gated potassium channel activity; • delayed rectifier potassium channel activity; • voltage-gated ion channel activity involved in regulation of presynaptic membrane potential;
Cellular component	• integral component of membrane; • vesicle; • perikaryon; • postsynaptic membrane; • cell projection; • membrane; • voltage-gated potassium channel complex; • cell membrane; • synapse; • integral component of plasma membrane; • intracellular; • neuronal cell body membrane; • axon; • cell junction; • terminal bouton; • neuronal cell body; • dendrite; • basolateral plasma membrane; • apical plasma membrane; • axolemma; • neuron projection; • presynaptic membrane; • dendrite membrane;
Biological process	• response to organic cyclic compound; • protein heterooligomerization; • regulation of insulin secretion; • response to nerve growth factor; • regulation of ion transmembrane transport; • cellular response to toxic substance; • response to magnesium ion; • ion transport; • globus pallidus development; • nitric oxide-cGMP-mediated signaling pathway; • potassium ion transport; • ion transmembrane transport; • transmembrane transport; • response to amine; • positive regulation of potassium ion transmembrane transport; • cellular response to nitric oxide; • response to light intensity; • response to ethanol; • protein homooligomerization; • response to toxic substance; • cellular response to ammonium ion; • potassium ion transmembrane transport; • positive regulation of voltage-gated potassium channel activity; • regulation of presynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	3747
	268345
	ENSG00000166006
	ENSMUSG00000035681
	Q96PR1
	Q14B80
NM_001260497; NM_001260498; NM_001260499; NM_139136; NM_139137;
	NM_153748
	NM_001025581; NM_001359752; NM_001359753; NM_001379643; NM_001379644
NP_001247426; NP_001247427; NP_001247428; NP_631874; NP_631875;
	NP_715624
	NP_001020752; NP_001346681; NP_001346682; NP_001366572; NP_001366573
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium voltage-gated channel subfamily C member 2 is a protein that in humans is encoded by the KCNC2 gene.[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2).[7]

Expression pattern

K_v3.1 and K_v3.2 channels are prominently expressed in neurons that fire at high frequency. K_v3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of the neocortex, hippocampus, and caudate nucleus; terminal fields of thalamocortical projections), and in retinal ganglion cells.[8][9][7]

Physiological role

K_v3.1/K_v3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.[9][10] Sometimes in heteromeric complexes with K_v3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.[7][8]

Pharmacological properties

K_v3.2 currents in heterologous systems are highly sensitive to external tetraethylammonium (TEA) or 4-aminopyridine (4-AP) (IC₅₀ values are 0.1 mM for both of the drugs).[7][9] This can be useful in identifying native channels.[9]

Transcript variants

There are four transcript variants of K_v3.2 gene: K_v3.2a, K_v3.2b, K_v3.2c, K_v3.2d. K_v3.2 isoforms differ only in their C-terminal sequence.[11]

References

GRCh38: Ensembl release 89: ENSG00000166006 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035681 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711–5. doi:10.1007/BF00357794. PMID 8111118. S2CID 24121259.
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
Kolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat". Retrieved 2008-10-20.
Rudy B, McBain CJ (September 2001). "K_v3 channels: voltage-gated K⁺ channels designed for high-frequency repetitive firing". Trends in Neurosciences. 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID 11506885. S2CID 36100588.
Lien CC, Jonas P (March 2003). "K_v3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience. 23 (6): 2058–68. doi:10.1523/JNEUROSCI.23-06-02058.2003. PMC 6742035. PMID 12657664.
Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of K_v3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1 MOLECULAR AND): 304–43. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID 10414303. S2CID 25289187.

External links

Kv3.2+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
KCNC2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166006 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035681 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8111118-5] Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes". Mamm Genome. 4 (12): 711–5. doi:10.1007/BF00357794. PMID 8111118. S2CID 24121259.

[pmid16382104-6] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[Gutman-7] Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol. Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

[y-8] Kolodin YO (2008-04-27). "Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat". Retrieved 2008-10-20.

[Rudy1-9] Rudy B, McBain CJ (September 2001). "K_v3 channels: voltage-gated K⁺ channels designed for high-frequency repetitive firing". Trends in Neurosciences. 24 (9): 517–26. doi:10.1016/S0166-2236(00)01892-0. PMID 11506885. S2CID 36100588.

[Lien-10] Lien CC, Jonas P (March 2003). "K_v3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons". Journal of Neuroscience. 23 (6): 2058–68. doi:10.1523/JNEUROSCI.23-06-02058.2003. PMC 6742035. PMID 12657664.

[Rudy2-11] Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999). "Contributions of K_v3 channels to neuronal excitability". Annals of the New York Academy of Sciences. 868 (1 MOLECULAR AND): 304–43. doi:10.1111/j.1749-6632.1999.tb11295.x. PMID 10414303. S2CID 25289187.