KCNK7

Potassium channel, subfamily K, member 7, also known as KCNK7 or K_2P7.1 is a protein which is encoded in humans by the KCNK7 gene. K_2P7.1 is a potassium channel containing two pore-forming P domains.[5][6][7] Multiple transcript variants encoding different isoforms have been found for this gene.[8]

KCNK7
Identifiers
Aliases	KCNK7, K2p7.1, TWIK3, potassium two pore domain channel subfamily K member 7
External IDs	OMIM: 603940 MGI: 1341841 HomoloGene: 43131 GeneCards: KCNK7
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,592,855 bp[1] End 65,595,996 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,704,367 bp[2] End 5,707,109 bp[2]
Gene ontology Molecular function • potassium channel activity • voltage-gated ion channel activity • potassium ion leak channel activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • ion transport • stabilization of membrane potential • potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10089	16530
Ensembl	ENSG00000173338	ENSMUSG00000024936
UniProt	Q9Y2U2	Q9Z2T1
RefSeq (mRNA)	NM_033456 NM_005714 NM_033347 NM_033348 NM_033455	NM_001004138 NM_010609
RefSeq (protein)	NP_005705 NP_203133 NP_203134 NP_258416	NP_034739
Location (UCSC)	Chr 11: 65.59 – 65.6 Mb	Chr 19: 5.7 – 5.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.[8]

See also

• Tandem pore domain potassium channel

References

1. GRCh38: Ensembl release 89: ENSG00000173338 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024936 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
6. Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
7. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
8. "Entrez Gene: potassium channel".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
• Salinas M, Reyes R, Lesage F, et al. (1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
• Medhurst AD, Rennie G, Chapman CG, et al. (2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery". Brain Res. Mol. Brain Res. 86 (1–2): 101–14. doi:10.1016/S0169-328X(00)00263-1. PMID 11165377.

External links

• KCNK7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNK7 human gene location in the UCSC Genome Browser.
• KCNK7 human gene details in the UCSC Genome Browser.