NLRP5

NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis.[5][6] NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals.

NLRP5
Identifiers
AliasesNLRP5, CLR19.8, MATER, NALP5, PAN11, PYPAF8, NLR family, pyrin domain containing 5, NLR family pyrin domain containing 5
External IDsOMIM: 609658 MGI: 1345193 HomoloGene: 65105 GeneCards: NLRP5
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.43Start55,999,726 bp[1]
End56,061,810 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

126206

23968

Ensembl

ENSG00000171487

ENSMUSG00000015721

UniProt

P59047

Q9R1M5

RefSeq (mRNA)

NM_153447

NM_001039143
NM_011860
NM_001305857

RefSeq (protein)

NP_703148

NP_001034232
NP_001292786
NP_035990

Location (UCSC)Chr 19: 56 – 56.06 MbChr 7: 23.39 – 23.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

In humans, the NLRP5 protein is encoded by the NLRP5 gene.[7][8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000171487 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015721 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wu X (February 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)". Hum. Reprod. 24 (2): 415–24. doi:10.1093/humrep/den403. PMID 19054779.
  6. Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (February 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells". J. Reprod. Dev. 56 (1): 41–8. doi:10.1262/jrd.09-098a. PMID 19815987.
  7. "Entrez Gene: NLR family".
  8. Tong ZB, Bondy CA, Zhou J, Nelson LM (April 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development". Hum. Reprod. 17 (4): 903–11. doi:10.1093/humrep/17.4.903. PMID 11925379.
  9. Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.

Further reading


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