NLRC3

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.[5] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.[6] NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation.[7]

NLRC3
Identifiers
Aliases	NLRC3, CLR16.2, NOD3, NLR family, CARD domain containing 3, NLR family CARD domain containing 3
External IDs	OMIM: 615648 MGI: 2444070 HomoloGene: 18720 GeneCards: NLRC3
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 3,539,033 bp[1] End 3,577,403 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 3,945,007 bp[2] End 3,976,632 bp[2]
Gene ontology Molecular function • nucleotide binding • ATP binding • GO:0001948 protein binding • phosphatidylinositol 3-kinase regulatory subunit binding • molecular function Cellular component • cytoplasm • microtubule organizing center • cytosol • perinuclear region of cytoplasm Biological process • negative regulation of interleukin-6 production • negative regulation of tumor necrosis factor production • I-kappaB kinase/NF-kappaB signaling • negative regulation of NF-kappaB transcription factor activity • T cell activation • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of phosphatidylinositol 3-kinase signaling • negative regulation of interferon-alpha production • negative regulation of interferon-beta production • negative regulation of innate immune response • negative regulation of fibroblast proliferation • negative regulation of epithelial cell proliferation • negative regulation of inflammatory response • negative regulation of cytokine production involved in inflammatory response • negative regulation of NLRP3 inflammasome complex assembly • negative regulation of NIK/NF-kappaB signaling • GO:0007243 intracellular signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	197358	268857
Ensembl	ENSG00000167984	ENSMUSG00000049871
UniProt	Q7RTR2	Q5DU56
RefSeq (mRNA)	NM_178844	NM_001081280 NM_175547
RefSeq (protein)	NP_849172	NP_001074749 NP_780756
Location (UCSC)	Chr 16: 3.54 – 3.58 Mb	Chr 16: 3.95 – 3.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000167984 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049871 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.
6. Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.
7. Karki, Rajendra; Man, Si Ming; Malireddi, R. K. Subbarao; Kesavardhana, Sannula; Zhu, Qifan; Burton, Amanda R.; Sharma, Bhesh Raj; Qi, Xiaopeng; Pelletier, Stephane; Vogel, Peter; Rosenstiel, Philip (December 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.