NLRP14

NLRP14, short for NOD-like receptor family pyrin domain containing 14, is an intracellular protein of mammals associated with a role in spermatogenesis. It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.[5] NLRP14 is found exclusively in the testes where it is expressed within spermatogonia, spermatocytes and spermatids.[6]

NLRP14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N1J, 4N1K, 4N1L
Identifiers
Aliases	NLRP14, CLR11.2, GC-LRR, NALP14, NOD5, PAN8, NLR family, pyrin domain containing 14, NLR family pyrin domain containing 14
External IDs	OMIM: 609665 MGI: 1924108 HomoloGene: 18531 GeneCards: NLRP14
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 7,020,446 bp[1] End 7,071,308 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 107,166,990 bp[2] End 107,198,102 bp[2]
Gene ontology Molecular function • ATP binding • nucleotide binding Cellular component • cytoplasm Biological process • cell differentiation • multicellular organism development • spermatogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	338323	76858
Ensembl	ENSG00000158077	ENSMUSG00000016626
UniProt	Q86W24	Q6B966
RefSeq (mRNA)	NM_176822	NM_001002894
RefSeq (protein)	NP_789792	NP_001002894
Location (UCSC)	Chr 11: 7.02 – 7.07 Mb	Chr 7: 107.17 – 107.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000158077 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000016626 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
6. Westerveld GH, Korver CM, van Pelt AM, et al. (December 2006). "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure". Hum. Reprod. 21 (12): 3178–84. doi:10.1093/humrep/del293. PMID 16931801.

Further reading

• Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
• Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human NACHT, LRR and PYD domains-containing protein 14 (NLRP14)