NLRP8

NLRP8, short for NOD-like receptor family pyrin domain containing 8, is an intracellular protein that is expressed in the ovaries, testes, and preimplantation embryos of mammals.[3][4] It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.

NLRP8
Identifiers
Aliases	NLRP8, CLR19.2, NALP8, NOD16, PAN4, NLR family, pyrin domain containing 8, NLR family pyrin domain containing 8
External IDs	OMIM: 609659 HomoloGene: 82360 GeneCards: NLRP8
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.43 Start 55,947,832 bp[1] End 55,988,629 bp[1]
Gene ontology Molecular function • nucleotide binding • ATP binding • molecular function Cellular component • cytoplasm • cellular component Biological process • neuron death Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	126205	n/a
Ensembl	ENSG00000179709	n/a
UniProt	Q86W28	n/a
RefSeq (mRNA)	NM_176811 NM_001317000	n/a
RefSeq (protein)	NP_001303929 NP_789781	n/a
Location (UCSC)	Chr 19: 55.95 – 55.99 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000179709 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Ponsuksili S, Brunner RM, Goldammer T, et al. (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. doi:10.1095/biolreprod.105.045096. PMID 16339045.
4. Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9: 202. doi:10.1186/1471-2148-9-202. PMC 2735741. PMID 19682372.

Further reading

• Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
• Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
• Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.