Casein kinase 1, alpha 1

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.[5]

CSNK1A1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCSNK1A1, CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975, casein kinase 1 alpha 1
External IDsOMIM: 600505 MGI: 1934950 HomoloGene: 111694 GeneCards: CSNK1A1
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q32Start149,492,982 bp[1]
End149,551,471 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1452

93687

Ensembl

ENSG00000113712

ENSMUSG00000024576

UniProt

P48729

Q6PJ87

RefSeq (mRNA)

NM_001025105
NM_001271741
NM_001271742
NM_001892

NM_146087
NM_001357498
NM_001357499
NM_001357500

RefSeq (protein)

NP_001020276
NP_001258670
NP_001258671
NP_001883

NP_666199
NP_001344427
NP_001344428
NP_001344429

Location (UCSC)Chr 5: 149.49 – 149.55 MbChr 18: 61.56 – 61.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

Casein kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1[6][7] and AXIN1.[8]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000113712 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024576 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tapia C, Featherstone T, Gómez C, Taillon-Miller P, Allende CC, Allende JE (Aug 1994). "Cloning and chromosomal localization of the gene coding for human protein kinase CK1". FEBS Letters. 349 (2): 307–12. doi:10.1016/0014-5793(94)00679-2. PMID 8050587. S2CID 19071414.
  6. Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430. S2CID 84792445.
  7. Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A (Jun 2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry. 276 (22): 18757–64. doi:10.1074/jbc.M010005200. PMID 11278595.
  8. Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.

Further reading


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