Thiethylperazine

Thiethylperazine (Torecan) is an antiemetic of the phenothiazine class. Though it was never licensed or used as an antipsychotic, it may have such effects.

Thiethylperazine

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	R06AD03 (WHO)
Pharmacokinetic data
Protein binding	60%
Identifiers
IUPAC name 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
CAS Number	1420-55-9
PubChem CID	5440
IUPHAR/BPS	7306
DrugBank	DB00372
ChemSpider	5245
UNII	8ETK1WAF6R
KEGG	D02354
ChEBI	CHEBI:9544
ChEMBL	ChEMBL1378
CompTox Dashboard (EPA)	DTXSID1023651
ECHA InfoCard	100.014.381
Chemical and physical data
Formula	C22H29N3S2
Molar mass	399.62 g·mol^−1
3D model (JSmol)	Interactive image
SMILES S(c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4)CC
InChI InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3 Key:XCTYLCDETUVOIP-UHFFFAOYSA-N
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Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.[1]

References

1. Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, et al. (October 2011). "Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice". The Journal of Clinical Investigation. 121 (10): 3924–31. doi:10.1172/JCI57867. PMC 3195473. PMID 21881209. Lay summary – Science Daily.