Secologanin synthase
In enzymology, a secologanin synthase (EC 1.14.19.62, was wrongly classified as EC 1.3.3.9 in the past) is an enzyme that catalyzes the chemical reaction
- loganin + NADPH + H+ + O2 secologanin + NADP+ + 2 H2O
| secologanin synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.19.62 | ||||||||
| CAS number | 258339-71-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 4 substrates of this enzyme are loganin, NADPH, H+, and O2, whereas its 3 products are secologanin, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is loganin:oxygen oxidoreductase (ring-cleaving). This enzyme participates in indole and ipecac alkaloid biosynthesis.
References
- Yamamoto H, Katano N, Ooi A, Inoue K (2000). "Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P450". Phytochemistry. 53 (1): 7–12. doi:10.1016/S0031-9422(99)00471-9. PMID 10656401.
- Strack D, Matern U, Schroder J (2000). "Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase". Plant J. 24 (6): 797–804. doi:10.1046/j.1365-313x.2000.00922.x. PMID 11135113.
- Yamamoto H, Katano N, Ooi Y, Inoue K (1999). "Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures". Phytochemistry. 50 (3): 417–422. doi:10.1016/S0031-9422(98)00613-X.
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