CYP2W1

CYP2W1 (cytochrome P450, family 2, subfamily W, polypeptide 1) is a protein that in humans is encoded by the CYP2W1 gene.[5]

CYP2W1
Identifiers
Aliases	CYP2W1, cytochrome P450 family 2 subfamily W member 1
External IDs	OMIM: 615967 MGI: 3616076 HomoloGene: 69239 GeneCards: CYP2W1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.3 Start 983,181 bp[1] End 989,640 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 139,352,617 bp[2] End 139,357,033 bp[2]
Gene ontology Molecular function • iron ion binding • oxidoreductase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • metal ion binding • monooxygenase activity • arachidonic acid epoxygenase activity • steroid hydroxylase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Cellular component • cell surface • cell membrane • endoplasmic reticulum lumen • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • cytoplasm • intracellular membrane-bounded organelle Biological process • oxidation-reduction process • xenobiotic metabolic process • epoxygenase P450 pathway • organic acid metabolic process • exogenous drug catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54905	545817
Ensembl	ENSG00000073067	ENSMUSG00000029541
UniProt	Q8TAV3	E9Q816
RefSeq (mRNA)	NM_017781	NM_001160265
RefSeq (protein)	NP_060251	NP_001153737
Location (UCSC)	Chr 7: 0.98 – 0.99 Mb	Chr 5: 139.35 – 139.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.[6] CYP2W1 is an interesting enzyme since it is mainly expressed in tumors and not in normal human tissue.

References

1. GRCh38: Ensembl release 89: ENSG00000073067 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029541 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gerhard DS, Wagner L, Feingold EA, et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
6. "Entrez Gene: CYP2W1".

External links

• Human CYP2W1 genome location and CYP2W1 gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hanzawa Y, Sasaki T, Mizugaki M, et al. (2008). "Genetic polymorphisms and haplotype structures of the human CYP2W1 gene in a Japanese population". Drug Metab. Dispos. 36 (2): 349–52. doi:10.1124/dmd.107.019141. PMID 17998294. S2CID 5123383.
• Yoshioka H, Kasai N, Ikushiro S, et al. (2006). "Enzymatic properties of human CYP2W1 expressed in Escherichia coli". Biochem. Biophys. Res. Commun. 345 (1): 169–74. doi:10.1016/j.bbrc.2006.04.080. PMID 16677611.
• Karlgren M, Gomez A, Stark K, et al. (2006). "Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1". Biochem. Biophys. Res. Commun. 341 (2): 451–8. doi:10.1016/j.bbrc.2005.12.200. PMID 16426568.
• Gomez A, Karlgren M, Edler D, et al. (2007). "Expression of CYP2W1 in colon tumors: regulation by gene methylation". Pharmacogenomics. 8 (10): 1315–25. doi:10.2217/14622416.8.10.1315. PMID 17979506.
• Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.