CYP3A7

CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[5] The gene location is 7q22.1.[6]

CYP3A7
Identifiers
Aliases	CYP3A7, CP37, CYPIIIA7, P-450(HFL33), P-450111A7, P450-HFLA, cytochrome P450 family 3 subfamily A member 7, P450HLp2
External IDs	OMIM: 605340 MGI: 88610 HomoloGene: 133564 GeneCards: CYP3A7
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 99,684,957 bp[1] End 99,735,196 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 76.89 cM Start 137,892,932 bp[2] End 137,921,619 bp[2]
Gene ontology Molecular function • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • aromatase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • iron ion binding • oxidoreductase activity • heme binding • oxygen binding • metal ion binding • steroid hydroxylase activity • estrogen 16-alpha-hydroxylase activity • monooxygenase activity • estrogen 2-hydroxylase activity Cellular component • endoplasmic reticulum membrane • organelle membrane • intracellular membrane-bounded organelle • membrane • endoplasmic reticulum Biological process • xenobiotic metabolic process • lipid hydroxylation • steroid metabolic process • oxidation-reduction process • estrogen metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1551	13113
Ensembl	ENSG00000160870	ENSMUSG00000029727
UniProt	P24462	Q64464
RefSeq (mRNA)	NM_000765	NM_007819
RefSeq (protein)	NP_000756	NP_031845
Location (UCSC)	Chr 7: 99.68 – 99.74 Mb	Chr 5: 137.89 – 137.92 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[7]

Notable alleles

The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000160870 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029727 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. doi:10.1093/oxfordjournals.jbchem.a122632. PMID 2722762.
6. "Cytochrome P450, Subfamily IIIA, Polypeptide 7". OMIM. Retrieved March 14, 2013.
7. Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics. 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID 10898111.
8. CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer

External links

• CYP3A7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CYP3A7 genome location and CYP3A7 gene details page in the UCSC Genome Browser.