Phytoene desaturase (3,4-didehydrolycopene-forming)

Phytoene desaturase (3,4-didehydrolycopene-forming) (EC 1.3.99.30, 5-step phytoene desaturase, five-step phytoene desaturase, phytoene desaturase (ambiguous), Al-1) is an enzyme with systematic name 15-cis-phytoene:acceptor oxidoreductase (3,4-didehydrolycopene-forming).[1][2] This enzyme catalyses the following chemical reaction

15-cis-phytoene + 5 acceptor all-trans-3,4-didehydrolycopene + 5 reduced acceptor (overall reaction)
(1a) 15-cis-phytoene + acceptor all-trans-phytofluene + reduced acceptor
(1b) all-trans-phytofluene + acceptor all-trans-zeta-carotene + reduced acceptor
(1c) all-trans-zeta-carotene + acceptor all-trans-neurosporene + reduced acceptor
(1d) all-trans-neurosporene + acceptor all-trans-lycopene + reduced acceptor
(1e) all-trans-lycopene + acceptor all-trans-3,4-didehydrolycopene + reduced acceptor
Phytoene desaturase (3,4-didehydrolycopene-forming)
Identifiers
EC number1.3.99.30
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is involved in carotenoid biosynthesis.

See also

References
  1. Hausmann A, Sandmann G (July 2000). "A single five-step desaturase is involved in the carotenoid biosynthesis pathway to beta-carotene and torulene in Neurospora crassa". Fungal Genetics and Biology. 30 (2): 147–53. doi:10.1006/fgbi.2000.1212. PMID 11017770.
  2. Estrada AF, Maier D, Scherzinger D, Avalos J, Al-Babili S (November 2008). "Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation". Fungal Genetics and Biology. 45 (11): 1497–505. doi:10.1016/j.fgb.2008.09.001. PMID 18812228.
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