Fumarate reductase

Fumarate reductase is the enzyme that converts fumarate to succinate, and is important in microbial metabolism as a part of anaerobic respiration.[1]

Succinate + acceptor <=> fumarate + reduced acceptor

Fumarate reductases can be divided into two classes depending on the electron acceptor:

• Fumarate reductase (quinol) (EC 1.3.5.4)

  The membrane-bound enzyme covalently linked to flavin cofactors, which is composed of 3 or 4 subunits, transfers electrons from a quinol to fumarate. This class of enzyme is thus involved in the production of ATP by oxidative phosphorylation.[1]

• Fumarate reductase (NADH) (EC 1.3.1.6)

  The enzyme is monomeric and soluble, and can reduce fumarate independently from the electron transport chain.[2] Fumarate reductase is absent from all mammalian cells.

References

1. Tielens, A.G.; van Hellemond, J.J. (1998). "The electron transport chain in anearobically functioning eukaryotes". Biochim. Biophys. Acta. 1365: 71–78. doi:10.1016/s0005-2728(98)00045-0.
2. Camarasa; et al. (2007). "Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1". Yeast. 24: 391–401. doi:10.1002/yea.1467.

External links

• Fumarate+Reductase at the US National Library of Medicine Medical Subject Headings (MeSH)