SRD5A3

Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene.[5][6] It is one of three forms of 5α-reductase.

SRD5A3
Identifiers
Aliases	SRD5A3, CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1, steroid 5 alpha-reductase 3
External IDs	OMIM: 611715 MGI: 1930252 HomoloGene: 41385 GeneCards: SRD5A3
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q12 Start 55,346,242 bp[1] End 55,373,100 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.3 Start 76,140,271 bp[2] End 76,155,504 bp[2]
Gene ontology Molecular function • oxidoreductase activity, acting on the CH-CH group of donors • cholestenone 5-alpha-reductase activity • oxidoreductase activity • 3-oxo-5-alpha-steroid 4-dehydrogenase activity • oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor • polyprenol reductase activity Cellular component • cytoplasm • integral component of membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum Biological process • lipid metabolism • polyprenol catabolic process • androgen biosynthetic process • protein glycosylation • dolichol metabolic process • dolichyl diphosphate biosynthetic process • oxidation-reduction process • dolichol-linked oligosaccharide biosynthetic process • dolichol biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79644	57357
Ensembl	ENSG00000128039	ENSMUSG00000029233
UniProt	Q9H8P0	Q9WUP4
RefSeq (mRNA)	NM_024592	NM_020611
RefSeq (protein)	NP_078868	NP_065636
Location (UCSC)	Chr 4: 55.35 – 55.37 Mb	Chr 5: 76.14 – 76.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Congenital disorder of glycosylation
• Kahrizi syndrome, a syndrome caused by a mutation in this gene

References

1. GRCh38: Ensembl release 89: ENSG00000128039 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029233 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: steroid 5 alpha-reductase 3".
6. Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H (January 2008). "Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer". Cancer Sci. 99 (1): 81–6. doi:10.1111/j.1349-7006.2007.00656.x. PMID 17986282. S2CID 51733620.

Further reading

• Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocr. Rev. 25 (6): 947–70. doi:10.1210/er.2003-0030. PMID 15583024.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cantagrel V, Lefeber DJ, Ng BG, et al. (2010). "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder". Cell. 142 (2): 203–17. doi:10.1016/j.cell.2010.06.001. PMC 2940322. PMID 20637498.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.