Gene D. Block

Gene David Block (born August 17, 1948)[1] is an American biologist, academic, inventor, and chancellor of the University of California, Los Angeles. Block has served as provost and professor of biology at the University of Virginia. While at the University of Virginia, Block interacted with Randy Pausch and is mentioned in his memoir, The Last Lecture.

Gene D. Block
6th Chancellor of the University of California, Los Angeles
Assumed office
August 1, 2007
Preceded byAlbert Carnesale
Norman Abrams (Acting)
Personal details
Born (1948-08-17) August 17, 1948
Monticello, New York, U.S.
ResidenceLos Angeles, California, U.S.
Alma materStanford University (BA)
University of Oregon (MS, PhD)

Before becoming chancellor of UCLA, Block had an extensive scientific career. His early work with mollusks investigated the structure and function of basal retinal neurons (BRN) in circadian photoentrainment. He was the first to discover a cell-autonomous circadian pacemaker and concluded that BRNs are both necessary and sufficient for photoentrainment. Later in his career, Block explored the molecular basis of circadian rhythms in mammals, and found that calcium flux was necessary for circadian rhythmicity. His most recent research, which he is still working on today, is largely focused on the effect that aging has on the circadian clock.

Early life

Block was born in Monticello, New York, the grandson of immigrants from Eastern Europe.[2] His father and uncle owned Mountain Dairies, a retail/wholesale distributor that served many of the hotels and camps that populated Catskill region of New York. During summers, he worked at the dairy as a truck driver, starting his days at 4am for early morning deliveries to summer camps and hotels. He also played piano in a trio that provided dance music for Saturday evening parties at several bungalow colonies within the "Borscht Belt". His hobbies included electronics and shortwave radio. He played varsity tennis at Monticello High School.

Education

Block received a BA from Stanford University in 1970, followed by his MS and PhD in 1972 and 1975, respectively, from the University of Oregon; all in psychology. From 1975–1978, he returned to Stanford for postdoctoral work with Donald Kennedy, who later became president of Stanford, and Colin Pittendrigh, who is known as the “father of biological timing." During this time Block studied how voluntary movements inhibit sensory feedback in the crayfish working in the Kennedy lab while studying issues of circadian biology with Colin Pittendrigh.

Career

University of Virginia

In 1978, Block became a member of the faculty in the Department of Biology of University of Virginia. Here, Block served as the vice provost for research from 1993-1998, vice president for research and public service from 1998-2001, and then in 2001 he was appointed as vice president and provost. Furthermore, during this time from 1991-2002, Block also served as the founding director of the National Science Foundation Science and Technology Center in Biological Timing.[3]

According to Block, “The center raised the national visibility of the University in biological and medical research, and gave us reputational leverage in the U.S. as well as in Europe and Japan...Most importantly, the center’s scientific accomplishments have been spectacular. We’ve done some high-risk research that has paid off greatly; some of it has fundamentally changed our understanding of biological processes.”[4]

One of the center’s biggest advances, largely by Joseph Takahashi, was the development of a mutant mouse that allowed for the identification and cloning of the “Clock” gene for the biological clock in a mouse in 1997. This was the first such gene to be identified at the molecular level in a mammal. This groundbreaking discovery was a result of the Clock Genome Project, which uses "forward genetics" to discover the genes regulating circadian clocks in mice, fruit flies, and plants. In addition, this work also led to the discovery of many other genes that regulate the biological clock.[5]

In 1997 and 1998, the reputable journal Science ranked the findings of the NSF Center in Biological Timings among the top 10 in biological research breakthroughs.[5]

Three of the NSF Center investigators, Jeffrey C. Hall, Michael Rosbash and Michael W. Young, received the 2017 Nobel Prize in Physiology or Medicine “for their discoveries of molecular mechanisms controlling the circadian rhythm.”[6]

UCLA

Block was appointed Chancellor of UCLA in 2007. His selection was announced on 21 December 2006, succeeding interim office holder Norman Abrams on 1 August 2007.[7]

In his inaugural address at UCLA, Block shared that his top priorities are to advance academic excellence, financial stability, diversity and civic engagement.[8] He has called for UCLA to deepen its engagement with Los Angeles and to increase access for students from underrepresented populations.[9] Under Block’s leadership, UCLA has seen an increase in student diversity on campus thanks to innovative efforts to recruit in diverse communities, and in 2015, UCLA reached pre-Prop. 209 levels, enrolling 279 African American freshmen, on par with the African American share of California public high school graduates.[10] UCLA has also increased the number of low- to middle-income students enrolled.[11] In 2019, UCLA was named the number one public university in the nation for the third consecutive year[12] and is consistently the most applied-to university, with more than 113,000 freshman applications for fall 2018.[13]

Block’s push for entrepreneurship on campus has fostered innovation and resulted in UCLA as the top university for creating startups based on campus research.[14] Additionally, to foster a deeper commitment to Los Angeles among UCLA students, Block oversaw the formation of the annual Volunteer Day event, in which thousands of students volunteer in schools, parks, food banks, veterans’ clinics and elsewhere at the beginning of each academic year.[15] Block also implemented UCLA’s two Grand Challenges, which are aimed at understanding, treating and preventing depression worldwide,[16] and moving Los Angeles toward 100 percent renewable energy, 100 percent locally sourced water and enhanced ecosystem health by 2050.[17]

During his tenure, Block has faced the challenge of steering UCLA through a severe budget crisis and tuition increases.[18] To address reductions in state funding and advance his priorities, Block is leading the largest fundraising campaign by a public university, aiming to raise $4.2 billion to support student scholarships and fellowships, research projects and new construction on campus in honor of UCLA’s centennial in 2019.[19]

Block holds UCLA faculty appointments in psychiatry and bio-behavioral sciences in the David Geffen School of Medicine and in integrative biology and physiology in the College of Letters and Science.[20]

On February 24, 2014, Block published an open letter to the campus community, expressing his opposition to Proposition 209, stating that the proposed merit-based selection system would damage diversity on campus..[21]

Scientific achievements

Cell-autonomous circadian pacemakers

While at the University of Virginia, Block worked extensively with his graduate student, Dr. Douglas G. McMahon, the 1986 winner of the Society for Neuroscience's Donald B. Lindsley Prize in Behavioral Neuroscience, on the functioning of the circadian pacemaker system at the cellular level in Bulla gouldiana. In 1984, Block's students conducted a continuous 74-hour intracellular recording in constant darkness that demonstrated that basal retinal neurons (BRN) in the Bulla eye exhibit clear circadian rhythms. These rhythms were also shown to be correlated one-for-one with compound action potentials produced by the optic nerve.[22] The change in membrane potential of the BRNs, which are electrically coupled, were shown to precede or occur simultaneously with the increased compound action potential frequency. An increase in firing frequency, and depolarization of the BRNs, was seen during the day, and the reverse at night. These results demonstrated that the BRNs were at minimum an output for the pacemaker pathway and provided evidence that they were good candidates for being circadian pacemaker neurons.

This research was expanded several years later by a breakthrough study published in Science in which Dr. Stephan Michel, and others working in Block's laboratory, demonstrated that circadian rhythms in BRN membrane conductance could persist spontaneously in isolated BRNs.[23] These spontaneous circadian rhythms were shown for BRNs in isolation from other retinal cells and in isolation from each other. They showed that these circadian rhythms in membrane conductance were caused primarily by a potassium ion current. BRNs in isolation demonstrated the same patterns shown in Block's previous work in which membrane conductance decreased at dawn and increased at dusk. That similar patterns were seen in isolated cells as in previous multiple cell cultures provided the first strong evidence that individual neurons possessed the capacity to generate circadian rhythms. This research definitively concluded that BRNs are both necessary and sufficient for photoentrainment in Bulla.

Necessity of calcium flux for rhythmicity

Block and colleagues hypothesized that ion movement across cell membranes plays a role in the generation of circadian rhythms. In 2005, his lab measured rhythms in rat suprachiasmatic nuclei (SCN) in various concentrations of calcium ions. Block found that as calcium concentration decreased, thus lowering the transmembrane ion movement, the amplitude of circadian rhythmicity also decreased.[24] With no calcium added, there was no circadian rhythm at all. Block's lab repeated the experiment with rat liver tissue and mouse SCN tissue and found the same results in each case. This demonstrated that across species and tissues, transmembrane calcium flux is necessary for the generation of circadian rhythms. However, there are still some questions about the function of calcium flux. In this experiment, Block also tried adding calcium channel Blockers to the tissues. Rhythmicity did disappear, but it took several cycles, and it is unknown why rhythmicity was not immediately abolished. In addition, Block suspects that calcium flux plays a role in the entrainment of the mammalian clock to the environment, similar to its role in mollusk entrainment.

Effects of aging on the circadian clock

Block has also studied the effect that aging has on the circadian system, collaborating with other leading chronobiologists including Michael Menaker. In 2002, he studied rhythmicity in rats of various ages and found that aging affected rhythmicity differently in different tissues. In the SCN, the intrinsic period shortened with age, while lung tissue often became arrhythmic (showing sporadic activity) and pineal and kidney tissues became phase advanced.[25] In 2008, Block exposed rats of various ages to different light cycles, and found that phase advances took longer in the SCN in old rats than in young rats, but pineal tissues advanced faster in older rats. Liver tissues did not phase shift at all when the light cycle was advanced.[26] These studies together have shown how complex the aging process is in the circadian system. Block notes that some, though not all, of these changes are likely influenced by diminishing synchronizing signals from the SCN. In 2006, Block observed that jetlag significantly increased the death rate in older mice, which highlights the medical importance of understanding the aging process of the circadian system.[27]

Inventions
Non-contact respiratory monitor for the prevention of Sudden Infant Death Syndromewith Dr. W. Otto Friesen, assigned to the Alumni Patents Foundation - Patent Issued.[3]
Sonic leveling deviceassigned to the Alumni Patents Foundation
Speaking aid for movement restricted patientsassigned to the Alumni Patents Foundation
Two chambered disposable hospital urinalassigned to the Alumni Patents Foundation
Remote slave alarm for battery operated fire and smoke sensorsassigned to University of Virginia Patent Foundation
AI operator fatigue monitorassigned to University of Virginia Patent Foundation

Honors and awards

Positions

Block has served on numerous advisory boards and committees, including:

Personal life

In 1970, Block married Carol Kullback, also from Monticello; they have two grown children.[31]

See also

References
  1. "Gene Gene Block". Marquis Who's Who.
  2. "Yes, Virginia, he's coming to lead UCLA".
  3. "Curriculum Vitae Gene D. Block". University of California. Archived from the original on 2013-04-19.
  4. "Clock stops on NSF biological timing center, but the momentum carries on". Archived from the original on 2008-09-07.
  5. "First Circadian Clock Gene Identified and Cloned in Mammals". National Science Foundation.
  6. "The 2017 Nobel Prize in Physiology or Medicine - Press Release". www.nobelprize.org. Retrieved 2018-06-19.
  7. Stogsdill, Carol. "Gene Block named new UCLA chancellor". UCLA Newsroom. Retrieved 2018-06-19.
  8. "Inaugural Address - UCLA Chancellor". UCLA Chancellor. Retrieved 2018-06-19.
  9. "Chancellor Gene Block – UCLA Office of the Chancellor". UCLA Chancellor. Retrieved 2018-06-19.
  10. Watanabe, Teresa. "How UCLA is boosting campus diversity, despite the ban on affirmative action". latimes.com. Retrieved 2018-06-19.
  11. "Some Colleges Have More Students From the Top 1 Percent Than the Bottom 60. Find Yours". Retrieved 2018-06-19.
  12. "2020 Top Public Colleges". US News & World Report. 2019-09-08. Retrieved 2019-09-10.
  13. Watanabe, Teresa. "Freshman applicants to UC soar to a new record, with UCLA again leading the way". latimes.com. Retrieved 2018-06-19.
  14. White, Ronald D. "UCLA grabs the top spot among 225 universities in business creation". latimes.com. Retrieved 2018-06-19.
  15. "UCLA Freshmen Tackle Volunteer Projects". NBC Southern California. Retrieved 2018-06-19.
  16. "In a Fight Against Depression, UCLA Relies on Technology". The Chronicle of Higher Education. 2018-03-08. Retrieved 2018-06-19.
  17. "Grand Challenges | About". grandchallenges.ucla.edu. Retrieved 2018-06-19.
  18. "Chancellor Block addresses scope of budget crisis, plans and priorities". UCLA Today. Archived from the original on 2010-06-15.
  19. Gordon, Larry Gordon, By Larry. "UCLA plans $4.2-billion fundraising drive to mark 2019 centennial". latimes.com. Retrieved 2018-06-19.
  20. "UCLA Chancellor Gene Block". University of California.
  21. The Impact of Proposition 209 and Our Duty to Our Students
  22. McMahon, Douglas G.; et al. (1984). "Cellular analysis of the Bulla ocular circadian pacemaker system". J Comp Physiol A. 155 (3): 379–385. doi:10.1007/bf00610591. S2CID 35743849.
  23. Michel, Stephan; et al. (1993). "Circadian Rhythm in Membrane Conductance Expressed in Isolated Neurons". Science. 259 (5092): 239–241. Bibcode:1993Sci...259..239M. doi:10.1126/science.8421785. PMID 8421785.
  24. Lundkvist, Gabriella; Yongho Kwak; Erin Davis; Hajime Tei; Gene Block (17 August 2005). "A calcium flux is required for circadian rhythm generation in mammalian pacemaker neurons". The Journal of Neuroscience. 25 (33): 7682–7686. doi:10.1523/JNEUROSCI.2211-05.2005. PMC 6725395. PMID 16107654.
  25. Yamazaki, Shin; Marty Straume; Hajime Tei; Yoshiyuki Sakaki; Michael Menaker; Gene Block (6 August 2002). "Effects of aging on central and peripheral mammalian clocks". Proceedings of the National Academy of Sciences. 99 (16): 10801–10806. Bibcode:2002PNAS...9910801Y. doi:10.1073/pnas.152318499. PMC 125050. PMID 12149444.
  26. Davidson, Alec; Shin Yamazaki; Deanna Arble; Michael Menaker; Gene Block (March 2008). "Resetting of central and peripheral circadian oscillators in aged rats". Neurobiology of Aging. 29 (3): 471–477. doi:10.1016/j.neurobiolaging.2006.10.018. PMC 1635489. PMID 17129640.
  27. Davidson, AJ; MT Sellix; J Daniel; S Yamazaki; M Menaker; GD Block (7 November 2006). "Chronic jet-lag increases mortality in aged mice". Curr Biol. 16 (21): R914-6. doi:10.1016/j.cub.2006.09.058. PMC 1635966. PMID 17084685.
  28. Wheeler, Mark. "Great Minds Gala raises more than $1 million for Semel Institute research". UCLA Newsroom. Retrieved 2018-03-20.
  29. "Academy Member Connection". www.amacad.org. Retrieved 2018-03-20.
  30. "Association of Pacific Rim Universities - Steering Committee". apru.org. Retrieved 2018-03-20.
  31. UCLA Magazine: "Block on Board" by Mary Daily July 1, 2007
Academic offices
Preceded by
Albert Carnesale		 Chancellor of the University of California, Los Angeles
2007 – present		 Incumbent
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