Diacylglycerol lipase

Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.[1] It catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol.

diacylglycerol lipase, alpha
Identifiers
SymbolDAGLA
Alt. symbolsC11orf11
NCBI gene747
HGNC1165
RefSeqNM_006133
UniProtQ9Y4D2
Other data
EC number3.1.1.-
LocusChr. 11 q12.3
diacylglycerol lipase, beta
Identifiers
SymbolDAGLB
NCBI gene221955
HGNC28923
RefSeqNM_139179
UniProtQ8NCG7
Other data
EC number3.1.1.-
LocusChr. 7 p22.1

Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.

Inhibitors

The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.

References
  1. Bisogno T, Howell F, Williams G, et al. (November 2003). "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain". J. Cell Biol. 163 (3): 463–8. doi:10.1083/jcb.200305129. PMC 2173631. PMID 14610053.
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