Leukotriene D4

Leukotriene D₄ (LTD₄) is one of the leukotrienes. Its main function in the body is to induce the contraction of smooth muscle, resulting in bronchoconstriction and vasoconstriction. It also increases vascular permeability. LTD₄ is released by basophils. Other leukotrienes that function in a similar manner are leukotrienes C₄ and E₄. Pharmacological agents that inhibit the function of these leukotrienes are leukotriene receptor antagonists (e.g. Zafirlukast, montelukast) and are useful for asthmatic individuals.

Eicosanoid synthesis. (Leukotrienes at right.)

Leukotriene D4

Identifiers
CAS Number	73836-78-9
3D model (JSmol)	Interactive image
ChEBI	CHEBI:28666
ChEMBL	ChEMBL288943
ChemSpider	4444401
MeSH	Leukotriene+D4
PubChem CID	5280878
UNII	5FNY4416UE
CompTox Dashboard (EPA)	DTXSID6040533
InChI InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 Key: YEESKJGWJFYOOK-IJHYULJSSA-N InChI=1/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 Key: YEESKJGWJFYOOK-IJHYULJSBX
SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O
Properties
Chemical formula	C25H40N2O6S
Molar mass	496.661 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

References