Befuraline

Befuraline (DIV-154) is a psychoactive drug and member of the piperazine chemical class which was developed in Germany in the 1970s.[1] Befuraline has stimulant and antidepressant effects and has seen some use in Germany and France, although it has never become widely used.[2] Befuraline's active metabolite benzylpiperazine is responsible for its effects.

Befuraline

Clinical data
ATC code	none
Identifiers
IUPAC name 1-benzofuran-2-yl(4-benzylpiperazin-1-yl)methanone
CAS Number	41717-30-0 41716-84-1
PubChem CID	68664
ChemSpider	61918
UNII	787AQ35GHR
ChEMBL	ChEMBL1076256
CompTox Dashboard (EPA)	DTXSID2046206
Chemical and physical data
Formula	C20H20N2O2
Molar mass	320.392 g·mol^−1
3D model (JSmol)	Interactive image
SMILES O=C(N1CCN(CC1)CC2=CC=CC=C2)C3=CC4=C(C=CC=C4)O3
InChI InChI=1S/C20H20N2O2/c23-20(19-14-17-8-4-5-9-18(17)24-19)22-12-10-21(11-13-22)15-16-6-2-1-3-7-16/h1-9,14H,10-13,15H2 Key:SRIJFPBZWUFLFD-UHFFFAOYSA-N
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See also

• Substituted piperazine
• Fipexide
• Piberaline

References

1. Boksay IJ, Popendiker K, Weber RO, Söder A (1979). "Synthesis and pharmacological activity of befuraline (N-benzo[b]furan-2-ylcarbonyl-N'-benzylpiperazine), a new antidepressant compound". Arzneimittel-Forschung. 29 (2): 193–204. PMID 582130.
2. Gastpar M, Gastpar G, Gilsdorf U (November 1985). "Befuraline, its safety and efficacy in depressed inpatients". Pharmacopsychiatry. 18 (6): 351–5. doi:10.1055/s-2007-1017396. PMID 4089015.