TXNDC2

Thioredoxin domain-containing protein 2 is a protein that in humans is encoded by the TXNDC2 gene.[5][6][7]

TXNDC2
Identifiers
Aliases	TXNDC2, SPTRX, SPTRX1, thioredoxin domain containing 2
External IDs	OMIM: 617790 MGI: 2389312 HomoloGene: 41856 GeneCards: TXNDC2
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.22 Start 9,885,726 bp[1] End 9,889,275 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E1.1 Start 65,637,507 bp[2] End 65,642,168 bp[2]
Gene ontology Molecular function • protein disulfide oxidoreductase activity • thioredoxin-disulfide reductase activity • oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor • protein-disulfide reductase activity Cellular component • cytoplasm Biological process • multicellular organism development • cellular response to oxidative stress • cell differentiation • glycerol ether metabolic process • cell redox homeostasis • spermatogenesis • cellular oxidant detoxification • oxidation-reduction process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84203	213272
Ensembl	ENSG00000168454	ENSMUSG00000050612
UniProt	Q86VQ3	Q6P902
RefSeq (mRNA)	NM_032243 NM_001098529	NM_001146002 NM_153519
RefSeq (protein)	NP_001091999 NP_115619	NP_001139474 NP_705739
Location (UCSC)	Chr 18: 9.89 – 9.89 Mb	Chr 17: 65.64 – 65.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000168454 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050612 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. Miranda-Vizuete A, Ljung J, Damdimopoulos AE, Gustafsson JA, Oko R, Pelto-Huikko M, Spyrou G (Aug 2001). "Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa" (PDF). J Biol Chem. 276 (34): 31567–74. doi:10.1074/jbc.M101760200. PMID 11399755. S2CID 8214150.
7. "Entrez Gene: TXNDC2 thioredoxin domain containing 2 (spermatozoa)".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jiménez A, Johansson C, Ljung J, et al. (2002). "Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity". FEBS Lett. 530 (1–3): 79–84. doi:10.1016/S0014-5793(02)03417-8. hdl:10261/47334. PMID 12387870. S2CID 24685421.
• Sadek CM, Damdimopoulos AE, Pelto-Huikko M, et al. (2002). "Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells". Genes Cells. 6 (12): 1077–90. doi:10.1046/j.1365-2443.2001.00484.x. hdl:10261/47418. PMID 11737268. S2CID 20869820.