TMX3

Protein disulfide-isomerase TMX3 is an enzyme that in humans is encoded by the TMX3 gene.[4][5]

TMX3
Identifiers
Aliases	TMX3, PDIA13, TXNDC10, thioredoxin related transmembrane protein 3
External IDs	OMIM: 616102 MGI: 2442418 HomoloGene: 10381 GeneCards: TMX3
Gene location (Mouse) Chr. Chromosome 18 (mouse)[1] Band 18|18 E4 Start 90,510,154 bp[1] End 90,543,267 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • isomerase activity • thiol oxidase activity • protein disulfide isomerase activity Cellular component • integral component of membrane • cell surface • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • platelet alpha granule membrane • cell membrane Biological process • peptidyl-cysteine oxidation • protein folding • response to endoplasmic reticulum stress • cell redox homeostasis • platelet degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54495	67988
Ensembl	ENSG00000166479	ENSMUSG00000024614
UniProt	Q96JJ7	Q8BXZ1
RefSeq (mRNA)	NM_019022	NM_198295
RefSeq (protein)	NP_061895 NP_001337441 NP_001337442 NP_001337443 NP_001337444 NP_001337445 NP_001337446	NP_938037
Location (UCSC)	n/a	Chr 18: 90.51 – 90.54 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCm38: Ensembl release 89: ENSMUSG00000024614 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Haugstetter J, Blicher T, Ellgaard L (Feb 2005). "Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum". J Biol Chem. 280 (9): 8371–80. doi:10.1074/jbc.M413924200. PMID 15623505.
5. "Entrez Gene: TXNDC10 thioredoxin domain containing 10".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Haugstetter J, Maurer MA, Blicher T, et al. (2008). "Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain". J. Biol. Chem. 282 (46): 33859–67. doi:10.1074/jbc.M706442200. PMID 17881353.